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Global impact of Salmonella type III secretion effector SteA on host cells

Opened Access Global impact of Salmonella type III secretion effector SteA on host cells

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Autor: Cardenal Muñoz, Elena
Gutiérrez, Gabriel
Ramos Morales, Francisco
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2014-07-11
Publicado en: Biochemical and Biophysical Research Communications, 449 (4), 419–424
Tipo de documento: Artículo
Resumen: Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems, encoded in pathogenicity islands 1 and 2. These systems translocate proteins called effectors into eukaryotic host cell. Effectors interfere with host signal transduction pathways to allow the internalization of pathogens and their survival and proliferation inside vacuoles. SteA is one of the few Salmonella effectors that are substrates of both type III secretion systems. Here, we used gene arrays and bioinformatics analysis to study the genetic response of human epithelial cells to SteA. We found that constitutive synthesis of SteA in HeLa cells leads to induction of genes related to extracellular matrix organization and regulation of cell proliferation and serine/threonine kinase signaling pathways. SteA also causes repression of genes related to immune processes a...
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Tamaño: 2.915Mb
Formato: PDF

URI: http://hdl.handle.net/11441/26807

DOI: 10.1016/j.bbrc.2014.05.056

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