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Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells

Opened Access Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells
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Autor: López Barneo, José
Ortega Sáenz, Patricia
Piruat Palomo, José Ignacio
García Fernández, María
Departamento: Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica
Fecha: 2006
ISBN/ISSN: 0470034998
9780470034996
Tipo de documento: Ponencia
Resumen: Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2-regulated K+ channels. The mechanisms involved in the detection of changes of O2 tension are unknown. Inhibition of the mitochondrial electron transport chain (ETC) at proximal and distal complexes induces external Ca2+-dependent catecholamine secretion. At saturating concentration of the ETC inhibitors, the cellular response to hypoxia is maintained. However, rotenone, a complex I blocker, selectively occludes the responsiveness to hypoxia of glomus cells in a dosedependent manner. The effect of rotenone is not mimicked by complex I inhibitors acting on different sites. We have also generated a knock-out mouse lacking SDHD, the small membrane-anchoring protein of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. Homozygous Sdhd -/- animals die at early embryonic stages. Heterozygous Sdhd +/- mice show a general...
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Tamaño: 264.0Kb
Formato: PDF

URI: http://hdl.handle.net/11441/18238

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