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Mostrando ítems 1-10 de 19
Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...
Artículo
Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression
(2012)
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite the growing number of studies linking the ...
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Artículo
New therapeutic perspectives in non-alcoholic steatohepatitis
(Elsevier, 2018-02-23)
Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able to improve steatosis, ballooning and fibrosis. Life-style interventions based on Mediterranean ...
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
(2012)
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ...
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Síndrome LPAC secundario a deleción del exón 4 del gen ABCB4 en un paciente con hepatitis C
(Arán Ediciones, S. L., 2014)
El síndrome LPAC (low-phospholipid-associated cholelithiasis syndrome) está asociado a mutaciones del gen ABCB4, que codifica la proteína MDR3, esencial en la secreción de fosfatidilcolina en las sales biliares. Este ...
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Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy
(Sociedad Española de Patología Digestiva, 2018-02-01)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or ...
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A Predictive Model for Selecting Patients with HCV Genotype 3 Chronic Infection with a High Probability of Sustained Virological Response to Peginterferon Alfa-2a/Ribavirin
(2016-03-18)
Background Access to direct-acting antiviral agents (DAAs) is restricted in some settings; thus, the Euro pean Association for the Study of the Liver recommends dual peginterferon/ribavirin (PegIFN/RBV) therapy wherever ...
Artículo
Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets
(PMC, 2016-08-22)
Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact mechanisms whereby quercetin impacts the HCV life cycle are not fully understood. We assessed the ...
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