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Mostrando ítems 1-10 de 27
Artículo
Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis. Modifications of elongation factor-2
(American Society for Biochemistry and Molecular Biology, 1996)
We have studied the effect of oxidative stress on protein synthesis in rat liver. Cumene hydroperoxide (CH) was used as an oxidant agent. The approach used was to determine the ribosomal state of aggregation and the time ...
Artículo
Physical exercise and myokines
(Spanish Society of Anti-Aging Medicine and Longevity, 2019-10)
Among the types of muscles present in the body is skeletal muscle, which is the one that allows the development of physical activity thanks to the contractile activity of its muscle cells. It is known that physical ...
Artículo
Folic acid supplementation: some practical aspects
(Federation of Anti-Aging Medicine Societies, 2012)
Since 1956, when Harman first postulated the free radical theory of aging, numerous studies have been carried out to test the protective action of antioxidants. One of these protective compounds used in antioxidant therapy ...
Artículo
Mitochondrial toxins and neurodegenerative diseases
(IMR Press, 2007)
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this ...
Artículo
Treatment with mesenchymal stem cells in an animal model of parkinson´s disease
(Federation of Anti-Aging Medicine Societies, 2015)
Artículo
Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions
(Elsevier, 2013)
Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by ...
Artículo
A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?
(JCDR, 2014)
Introduction: The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown to protect experimental stress-induced hyppocampal degeneration, could beneficially modulate ...
Artículo
The Emerging Role of Senotherapy in Cancer: A Comprehensive Review
(MDPI, 2023-07-22)
Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate ...
Artículo
Effect of Age and Lipoperoxidation in Rat and Human Adipose Tissue-Derived Stem Cells
(Hindawi, 2020)
A wide range of clinical applications in regenerative medicine were opened decades ago with the discovery of adult stem cells. Highly promising adult stem cells are mesenchymal stem/stromal cells derived from adipose tissue ...
Artículo
In vitro and in Vivo Protection by Melatonin Against the Decline of Elongation Factor-2 Caused by Lipid Peroxidation: Preservation of Protein Synthesis
(Wiley-Blackwell, 2012)
As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of the decline of translation in old animals are the modifications of elongation factor-2 (eEF- 2). eEF-2 ...