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Listar Artículos (Química Orgánica) por autor "Padrón, José M."
Mostrando ítems 1-15 de 15
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Artículo
Biotinylated selenocyanates: Potent and selective cytostatic agents
Roldán Peña, Jesús Miguel; Puerta, Adrián; Dinić, Jelena; Jovanović Stojanov, Sofija; González-Bakker, Aday; Hicke, Francisco J.; Mishra, Atreyee; Piyasaengthong, Akkharadet; Maya Castilla, Inés; Walton, James W.; Pešić, Milica; Padrón, José M.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Elsevier, 2023-04)Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ...
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Artículo
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
Velueta Viveros, Martha; Martínez Bailén, Macarena; Puerta, Adrián; Romero Hernández, Laura L.; Křen, Vladimír; Merino Montiel, Penélope; Montiel Smith, Sara; Fernandes, Miguel X.; Moreno Vargas, Antonio José; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Elsevier, 2022-10)Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
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Artículo
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
Begines Aguilar, Paloma; Martos Delgado, Sergio; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...
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Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
Martínez Montiel, Mónica; Romero Hernández, Laura L.; Giovannuzzi, Simone; Begines Aguilar, Paloma; Puerta, Adrián; Ahuja Casarín, Ana I.; Fernandes, Miguel X.; Merino Montiel, Penélope; Montiel Smith, Sara; Nocentini, Alessio; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ...
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Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
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Investigation of the Enantioselectivity of Acetylcholinesterase and Butyrylcholinesterase upon Inhibition by Tacrine-iminosugar Heterodimers
Vaaland, I. Caroline; López López, Óscar; Puerta, Adrián; Fernandes, Miguel X.; Padrón, José M.; Fernández-Bolaños Guzmán, José María; Sydnes, Magne O.; Lindback, Emil (Taylor & Francis, 2023)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing ...
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Iridium-and Palladium-Based Catalysts in the Pharmaceutical Industry
López López, Óscar; Padrón, José M. (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production ...
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Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance
Begines Aguilar, Paloma; Sevilla Horrillo, Lucía; Puerta, Adrián; Puckett, Rebeca; Bayort, Samuel; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (MDPI, 2020)Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ...
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New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
Roldán Peña, Jesús Miguel; Alejandre Ramos, Daniel; López López, Óscar; Maya Castilla, Inés; Lagunes, Irene; Padrón, José M.; Peña Altamira, Luis Emiliano; Bartolini, Manuela; Monti, Barbara; Bolognesi, Maria L.; Fernández-Bolaños Guzmán, José María (Elsevier, 2017)We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, ...
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Artículo
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
Lagunes, Irene; Begines Aguilar, Paloma; Silva, Adrián; Galán, Alexis R.; Puerta, Adrián; Fernandes, Miguel X.; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; López López, Óscar; Padrón, José M. (Elsevier, 2019-10-01)Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin ...
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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations
Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke, Francisco J.; Nocentini, Alessio; Fernandes, Miguel X.; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Multidisciplinary Digital Publishing Institute (MDPI), 2022)(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ...
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Artículo
Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties
Sánchez Fernández, Elena Matilde; García Hernández, Raquel; Gamarro, Francisco; Arroba, Ana I.; Aguilar Diosdado, Manuel; Padrón, José M.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Multidisciplinary Digital Publishing Institute (MDPI), 2021)sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a ...
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Artículo
Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
Romero Hernández, Laura L.; Merino Montiel, Penélope; Meza Reyes, Socorro; Vega Baez, José Luis; López López, Óscar; Padrón, José M.; Montiel Smith, Sara (Elsevier, 2018-01-01)Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and ...
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Artículo
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
Roldán Peña, Jesús Miguel; Romero Real, V.; Hicke, Javier; Maya Castilla, Inés; Franconetti García, Antonio; Lagunes, Irene; Padrón, José M.; Petralla, Sabrina; Poeta, Eleonora; Naldi, Marina; Bartolini, Manuela; Monti, Barbara; Bolognesi, Maria L.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Elsevier, 2019-11-01)Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the ...
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids
Sánchez Fernández, Elena Matilde; García Moreno, M. Isabel; García Hernández, Raquel; Padrón, José M.; García Fernández, José Manuel; Gamarro, Francisco; Ortiz Mellet, Carmen (MDPI, 2019)The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ...