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Artículo
Ciclos de mejora docente en la asignatura de Química General basados en el trabajo guiado
(Universidad de Sevilla, 2018)
En esta comunicación se presentan una estrategia de mejora docente progresiva basada en los denominados Ciclos de Mejora Docente, los cuales se han realizado en una parte del temario de la asignatura “Química General” ...
Artículo
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
(American Chemical Society, 2018)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out. The combination of the ...
Tesis Doctoral
Patente
Procedimiento para la obtención de secoiridoides dialdehídicos
(Oficina Española de Patentes y Marcas , 2018-02-07)
Procedimiento para la obtención de secoiridoides dialdehídicos.Esta invención se refiere un procedimiento para la obtención de secoiridoides dialdehídicos, tales como la oleaceína y oleocantal mediante el uso de DMSO. Este ...
Artículo
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
(Molecular Diversity Preservation International, 2018)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone ...
Artículo
Artículo
Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation
(Wiley, 2018)
Adiastereo- and highly enantioselective dynamic kinetic resolution (DKR) of configurationally labile hetero- biaryl ketones is described. The DKR proceeds by zinc- catalyze dhydrosilylation of the ...
Artículo
Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center
(MDPI, 2018)
Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step ...
Artículo
Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines
(MDPI AG, 2018)
The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. Our main target has been to depict a novel evaluation methodology via discussion through a ...