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Artículo
Functional analysis of saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis
(Oxford University Press, 2007)
Ribosome synthesis in eukaryotes requires a multitude oftrans-acting factors. These factors act at many steps as the pre-ribosomal particles travel from the nucleolus to the cytoplasm. In contrast to the well-studied ...
Artículo
Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
(Oxford University Press, 2018)
The contribution of most ribosomal proteins to ribo- some synthesis has been quite well analysed in Sac- charomyces cerevisiae . However, few yeast riboso- mal proteins still await characterization. Herein, we show ...
Artículo
Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The tyrosine kinase inhibitor Sorafenib (Sfb) remains the globally accepted treatment for advanced HCC. ...
Artículo
Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2019)
In Saccharomyces cerevisiae, more than 250 trans-acting factors are involved in the maturation of 40S and 60S ribosomal subunits. The expression of most of these factors is transcriptionally coregulated to ensure correct ...
Artículo
Overexpression of budding yeast protein phosphatase Ppz1 impairs translation
(Elsevier, 2020)
The Ser/Thr protein phosphatase Ppz1 from Saccharomyces cerevisiae is the best characterized member of a family of enzymes only found in fungi. Ppz1 is regulated in vivo by two inhibitory subunits, Hal3 and Vhs3, which are ...
Artículo
Increased sensitivity to protein synthesis inhibitors in cells lacking tmRNA
(Cold Spring Harbor Laboratory Press, 2001)
tmRNA (also known as SsrA or 10Sa RNA) is involved in a trans-translation reaction that contributes to the recycling of stalled ribosomes at the 3′ end of an mRNA lacking a stop codon or at an internal mRNA cluster of rare ...
Artículo
A novel endo-β-1,3-glucanase, BGN13.1, involved in the mycoparasitism of Trichoderma harzianum
(American Society for Microbiology, 1995)
The mycoparasitic fungus Trichoderma harzianum CECT 2413 produces at least three extracellular β-1,3-glucanases. The most basic of these extracellular enzymes, named BGN13.1, was expressed when either fungal cell wall ...
Artículo
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
(Wiley-Blackwell, 2018)
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) ...
Artículo
Balanced production of ribosome components is required for proper G/S transition in saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology Inc., 2013)
Artículo
The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits
(Oxford University Press, 2016)
The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes and consists of a conserved body and a eukaryote-specific N-terminal extension. In yeast, S31 is ...