Buscar
Mostrando ítems 1-10 de 21
Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed ...
Artículo
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation
(American Society for Biochemistry and Molecular Biology Inc., 2003)
THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and export such as Sub2 and Yra1. Mutations in any of the THO/TREX structural genes cause pleiotropic ...
Artículo
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
(American Society for Microbiology, 2009)
Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between transcription and mRNA export. Despite the relevance of R-loops in transcription-associated recombination, the ...
Artículo
Nab2p and the Thp1p-Sac3p Complex Functionally Interact at the Interface between Transcription and mRNA Metabolism
(Elsevier, 2003)
THP1 is a conserved eukaryotic gene whose null mutations confer, in yeast, transcription and genetic instability phenotypes and RNA export defects similar to those of the THO/TREX complex null mutations. In a search for ...
Artículo
Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
(Oxford University Press, 2007)
Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, but a study of repair of DSBs specifically induced during S-phase is lacking. Using an inverted-repeat ...
Artículo
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex
(American Society for Microbiology, 2006)
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein (mRNP) metabolism. THO mutations impair transcription and lead to increased transcrip ...
Artículo
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. The lack of a functional THO complex impairs transcription, leads to transcriptiondependent ...
Artículo
Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination
(Nature Publishing Group, 2006)
DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5–Smc6 ...
Artículo
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress
(American Society for Cell Biology, 2009)
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress activates the Hog1 SAPK, which modulates cell cycle ...
Artículo
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution of mRNP biogenesis and export in transcription-coupled repair (TCR). Interestingly, mutants of THO, ...