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Artículo
Prognostic value of CtIP/RBBP8 expression in breast cancer
(Wiley Open Access, 2013)
CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several ...
Artículo
The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
(Elsevier, 2018)
DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination (HR). The decision between these two routes of DNA repair is a key point of the DNA damage ...
Artículo
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
(Nature Publishing Group, 2021)
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration of RNA, has a profound effect on cell ...
Artículo
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
(Nature Research, 2019)
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is ...
Artículo
The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes
(Frontiers Media S.A., 2021)
The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures ...
Artículo
Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery
(MDPI, 2021-08)
The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. Four amphiphilic calixarenes were used. The length of the hydrophobic ...
Artículo
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
(Elsevier, 2020)
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 ...
Artículo
Speed matters: How subtle changes in DNA end resection rate affect repair
(Taylor & Francis, 2015)
The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, ...
Artículo
The COP9 signalosome is vital for timely repair of DNA double-strand breaks
(Oxford University Press, 2015)
The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response is the ATM protein kinase. We discovered that the COP9 signalosome (CSN) is a crucial player in ...
Artículo
Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice
(Oxford University Press, 2015)
DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation ...