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Mostrando ítems 1-10 de 33
Artículo
Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network
(National Academy of Sciences of the USA, 1997)
We have examined the role played by protein kinase A (PKA) in vesicle-mediated protein transport from the trans-Golgi network (TGN) to the cell surface. In vivo this transport step was inhibited by inhibitors of PKA catalytic ...
Artículo
Ceramide chain length–dependent protein sorting into selective endoplasmic reticulum exit sites
(American Association for the Advancement of Science, 2020)
Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport ...
Artículo
Determination of the lipid composition of the GPI anchor
(PLOS, 2021)
In eukaryotic cells, a subset of cell surface proteins is attached by the glycolipid glycosylphosphatidylinositol (GPI) to the external leaflet of the plasma membrane where they play important roles as enzymes, receptors, ...
Artículo
A Role for Lipids in Protein Sorting?
(Swiss Chemical Society, 2021)
Lipid and protein diversity provides structural and functional identity to the membrane compartments that define the eukaryotic cell. This compositional heterogeneity is maintained by the secretory pathway, which feeds ...
Artículo
Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface
(Elsevier, 2016)
In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational ...
Artículo
The ceramide synthase subunit lac1 regulates cell growth and size in fission yeast
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Cell division produces two viable cells of a defined size. Thus, all cells require mechanisms to measure growth and trigger cell division when sufficient growth has occurred. Previous data suggest a model in which growth ...
Artículo
Structural analysis of the GPI glycan
(PLOS, 2021)
Glycosylphosphatidylinositol (GPI) anchoring of proteins is an essential post-translational modification in all eukaryotes that occurs at the endoplasmic reticulum (ER) and serves to deliver GPI-anchored proteins (GPI-APs) ...
Tesis Doctoral
Control de calidad de la exportación selectiva del retículo endoplásmico mediada por lípidos
(2022-11-18)
El transporte selectivo de proteínas a lo largo de la ruta secretora (sorting) es un proceso esencial para mantener la compartimentalización funcional y homeostasis de la célula eucariótica. Además de la maquinaria proteica ...
Tesis Doctoral
Regulación de la estructura y función del complejo de Golgi por factores citosólicos y proteínas G heterotriméricas
(1996)
Las células eucariotas están organizadas en una serie de compartimentos delimitados por membranas lipídicas. En cada comportamiento se realizan actividades características, que son la expresión funcional de las moléculas ...
Artículo
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells
(Elsevier, 2012)
Sphingolipids are not only important components of membranes but also have functions in protein trafficking and intracellular signaling. The LCB1 gene encodes a subunit of the serine palmitoyltransferase, which is responsible ...