A Role for Lipids in Protein Sorting?
|Aguilera Romero, María Auxiliadora
Muñiz Guinea, Manuel
|Universidad de Sevilla. Departamento de Biología Celular
|Lipid and protein diversity provides structural and functional identity to the membrane compartments that define the eukaryotic cell. This compositional heterogeneity is maintained by the secretory pathway, which feeds ...
Lipid and protein diversity provides structural and functional identity to the membrane compartments that define the eukaryotic cell. This compositional heterogeneity is maintained by the secretory pathway, which feeds newly synthesized proteins and lipids to the endomembrane systems. The precise sorting of lipids and proteins through the pathway guarantees the achievement of their correct delivery. Although proteins have been shown to be key for sorting mechanisms, whether and how lipids contribute to this process is still an open discussion. Our laboratory, in collaboration with other groups, has recently addressed the long-postulated role of membrane lipids in protein sorting in the secretory pathway, by investigating in yeast how a special class of lipid-linked cell surface proteins are differentially exported from the endoplasmic reticulum. Here we comment on this interdisciplinary study that highlights the role of lipid diversity and the importance of protein-lipid interactions in sorting processes at the cell membrane.
|Ministerio de Ciencia, Innovación y Universidades (MICINN). España
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
|Aguilera Romero, M.A. y Muñiz Guinea, M. (2021). A Role for Lipids in Protein Sorting?. Chimia, 75 (12), 1026-1030.