Artículo
Ceramide chain length–dependent protein sorting into selective endoplasmic reticulum exit sites
Autor/es | Rodríguez Gallardo, Sofía
Kurokawa, Kazuo Sabido Bozo, Susana Cortés Gómez, Alejandro Ikeda, Atsuko Zoni, Valeria Aguilera Romero, María Auxiliadora Pérez Linero, Ana María López Martín, Sergio Muñiz Guinea, Manuel |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2020 |
Fecha de depósito | 2022-05-16 |
Publicado en |
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Resumen | Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport ... Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport is a longstanding fundamental question that still remains unanswered. Here, we conduct 3D simultaneous multicolor high-resolution live imaging to demonstrate in vivo that newly synthesized glycosylphosphatidylinositol-anchored proteins having a very long chain ceramide lipid moiety are clustered and sorted into specialized endoplasmic reticulum exit sites that are distinct from those used by transmembrane proteins. Furthermore, we show that the chain length of ceramide in the endoplasmic reticulum membrane is critical for this sorting selectivity. Our study provides the first direct in vivo evidence for lipid chain length–based protein cargo sorting into selective export sites of the secretory pathway. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Universidad de Sevilla Swiss National Science Foundation (SNFS) Swiss National Supercomputing Centre (CSCS) |
Identificador del proyecto | BFU2017-89700-P
VIPPIT-2020-I.5 JP25221103 JP17H06420 JP18H05275 |
Cita | Rodríguez Gallardo, S., Kurokawa, K., Sabido Bozo, S., Cortés Gómez, A., Ikeda, A., Zoni, V.,...,Muñiz Guinea, M. (2020). Ceramide chain length–dependent protein sorting into selective endoplasmic reticulum exit sites. Science Advances, 6 (50), eaba8237. |
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sciadv.aba8237.pdf | 4.552Mb | [PDF] | Ver/ | |