Artículo
The ceramide synthase subunit lac1 regulates cell growth and size in fission yeast
Autor/es | Flor Parra, Ignacio
Sabido Bozo, Susana Ikeda, Atsuko Hanaoka, Kazuki Aguilera Romero, María Auxiliadora Funato, Kouichi Muñiz Guinea, Manuel Lucena Hernández, Rafael |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-03-22 |
Publicado en |
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Premios | Premio Mensual Publicación Científica Destacada de la US. Facultad de Biología |
Resumen | Cell division produces two viable cells of a defined size. Thus, all cells require mechanisms to measure growth and trigger cell division when sufficient growth has occurred. Previous data suggest a model in which growth ... Cell division produces two viable cells of a defined size. Thus, all cells require mechanisms to measure growth and trigger cell division when sufficient growth has occurred. Previous data suggest a model in which growth rate and cell size are mechanistically linked by ceramide-dependent signals in budding yeast. However, the conservation of mechanisms that govern growth control is poorly understood. In fission yeast, ceramide synthase is encoded by two genes, Lac1 and Lag1. Here, we characterize them by using a combination of genetics, microscopy, and lipid analysis. We showed that Lac1 and Lag1 co-immunoprecipitate and co-localize at the endoplasmic reticulum. However, each protein generates different species of ceramides and complex sphingolipids. We further discovered that Lac1, but not Lag1, is specifically required for proper control of cell growth and size in Schizosaccharomyces pombe. We propose that specific ceramide and sphingolipid species produced by Lac1 are required for normal control of cell growth and size in fission yeast. |
Identificador del proyecto | P18-FRJ1132
VIPPIT-2020-I.5 JP19H02922 JP21K19088 BFU2017-89700-P |
Cita | Flor Parra, I., Sabido Bozo, S., Ikeda, A., Hanaoka, K., Aguilera Romero, M.A., Funato, K.,...,Lucena Hernández, R. (2022). The ceramide synthase subunit lac1 regulates cell growth and size in fission yeast. International Journal of Molecular Sciences, 23 (1), 303. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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The Ceramide Synthase Subunit.pdf | 4.049Mb | [PDF] | Ver/ | |