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      Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus 

      González Arzola, Katiuska; Guerra Castellano, Alejandra; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2021)
      Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...
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      Mitochondrial Factors in the Cell Nucleus 

      González Arzola, Katiuska; Díaz Quintana, Antonio Jesús (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
      The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene ...
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      Modulation of copper site properties by remote residues determines the stability of plastocyanins 

      Muñoz López, Francisco Jesús; Frutos Beltrán, Estrella; Díaz Moreno, Sofía; Díaz Moreno, Irene; Subías Peruga, Maria Gloria; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Elsevier, 2010)
      The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ...
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      Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism 

      González Rellán, María J.; Fernández, Uxía; Parracho, Tamara; Novoa, Eva; Fondevila, Marcos F.; Da Silva Lima, Natalia; Rodríguez, Amaia; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Nogueiras, Rubén (Elsevier, 2023)
      Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed ...
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      New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants 

      Martínez Fábregas, Jonathan; Díaz Moreno, Irene; González Arzola, Katiuska; Janocha, Simon; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Bernhardt, Rita; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (American Society for Biochemistry and Molecular Biology, 2013)
      Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ...
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      Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis 

      Roberti, Annalisa; Tejedor, Juan Ramón; Díaz Moreno, Irene; López, Virginia; Santamarina-Ojeda, Pablo; Pérez, Raúl F.; Urdinguio, Rocío G.; Concellón, Carmen; Martínez-Chantar, María Luz; Fernández Morera, Juan Luis; Díaz Quintana, Antonio Jesús; Amo, Vicente del; Fernández, Agustín F.; Fraga, Mario F. (Springer Nature, 2023-05-22)
      Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to ...
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      Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation 

      García Heredia, José Manuel; Díaz Moreno, Irene; Nieto Mesa, Pedro Manuel; Orzáez, Mar; Kocanis, Stella; Teixeira, Miguel; Pérez Payá, Enrique; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Elsevier, 2010)
      Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...
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      NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6 

      Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Molina Heredia, Fernando Publio; Nieto Mesa, Pedro Manuel; Hansson, Örjan; Rosa Acosta, Miguel Ángel de la; Karlsson, B. Göran (Elsevier, 2005)
      A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem ...
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      Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics 

      Díaz Moreno, Irene; Velázquez Cruz, Alejandro; Curran French, Seamus; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2018)
      Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ...
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      Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation. 

      González Arzola, Katiuska; Díaz Quintana, Antonio Jesús; Bernardo García, Noelia; Martínez Fábregas, Jonathan; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Elena-Real, Carlos A.; Velázquez Cruz, Alejandro; Gil Caballero, Sergio; Velázquez Campoy, Adrián; Szulc, Elzbieta; Gavilán Dorronzoro, María de la Paz; Ayala, Isabel; Arranz, Rocío; Ríos, Rosa M.; Salvatella, Xavier; Valpuesta, José María; Hermoso, Juan A.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Nature Research, 2022-10-11)
      The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...
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      Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria 

      Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Pérez Mejías, Gonzalo; Elena-Real, Carlos A.; González Arzola, Katiuska; García Mauriño, Sofía M.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (National Academy of Sciences, 2018)
      Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ...
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      Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation 

      Álvarez Córdoba, Mónica; Fernández Khoury, Aida; Villanueva Paz, Marina; Gómez Navarro, Carmen; Villalón García, Irene; Suárez Rivero, Juan M.; Povea Cabello, Suleva; Mata, Mario de la; Cotán, David; Talaverón Rey, Marta; Pérez Pulido, Antonio J.; Salas, Joaquín J.; Pérez Villegas, Eva Mª; Díaz Quintana, Antonio Jesús; Armengol, José A.; Sánchez Alcázar, José A. (Springer Nature, 2019)
      Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited neurologic disorders in which iron accumulates ...
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      Phosphorylation disrupts long-distance electron transport in cytochrome c 

      Gomila, Alexandre M.J.; Pérez Mejías, Gonzalo; Nin-Hill, Alba; Guerra Castellano, Alejandra; Casas Ferrer, Laura; Ortiz Tescari, Sthefany; Díaz Quintana, Antonio Jesús; Samitier, Josep; Rovira, Carme; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene; Gorostiza, Pau; Giannotti, Marina I.; Lagunas, Anna (Springer Nature, 2022)
      t has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the ...
    • Tesis Doctoral
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      Phosphorylation of cytochrome C: functional and structural features 

      Guerra Castellano, Alejandra (2017-01-27)
      Post-translational modifications often modulate protein function. Actually, phosphorylation of cytochrome c occurs in vivo ...
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      Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation 

      Velázquez Cruz, Alejandro; Baños Jaime, Blanca; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Frontiers Media S.A., 2021)
      Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation ...
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      Post-Translational Modifications of Cytochrome c in Cell Life and Disease 

      Guerra Castellano, Alejandra; Márquez Escudero, Inmaculada; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (MDPI, 2020)
      Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ...
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      PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ 

      Casado Combreras, Miguel Ángel; Rivero Rodríguez, Francisco; Elena-Real, Carlos A.; Molodenskiy, Dmitry; Díaz Quintana, Antonio Jesús; Martinho, Marlène; Gerbaud, Guillaume; González Arzola, Katiuska; Velázquez Campoy, Adrián; Svergun, Dmitri; Belle, Valérie; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2022)
      Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...
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      PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ 

      Casado Combreras, Miguel Ángel; Rivero Rodríguez, Francisco; Elena-Real, Carlos A.; Molodenskiy, Dmitry; Díaz Quintana, Antonio Jesús; Martinho, Marlène; Gerbaud, Guillaume; González Arzola, Katiuska; Velázquez Campoy, Adrián; Svergun, Dmitri; Belle, Valérie; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Research Network of Computational and Structural Biotechnology, 2022)
      Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...
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      Proposed mechanism for regulation of H2O2-induced programmed cell death in plants by binding of cytochrome c to 14-3-3 proteins 

      Elena-Real, Carlos A.; González Arzola, Katiuska; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Velázquez Campoy, Adrián; Desvoyes, Bénédicte; Gutiérrez, Crisanto; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Wiley-Blackwell, 2021-04)
      Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the ...
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      Protein crosslinking improves the thermal resistance of plastocyanin immobilized on a modified gold electrode 

      Olloqui Sariego, José Luis; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Calvente Pacheco, Juan José; Márquez Escudero, Inmaculada; Díaz Moreno, Irene; Andreu Fondacabe, Rafael Jesús (Elsevier, 2018-12)
      Increasing the thermal stability of immobilized proteins is a motivating goal for improving the performance of electrochemical ...