dc.creator | Romero Ben, Elena | es |
dc.creator | Cid, Juan José | es |
dc.creator | Assali, Mohyeddin | es |
dc.creator | Fernández García, Elisabet | es |
dc.creator | Wellinger, Ralf Erik | es |
dc.creator | Khiar, Noureddine | es |
dc.date.accessioned | 2020-06-29T10:32:41Z | |
dc.date.available | 2020-06-29T10:32:41Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Romero Ben, E., Cid, J.J., Assali, M., Fernández García, E., Wellinger, R.E. y Khiar, N. (2019). Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination. International Journal of Nanomedicine, 14, 3245-3263. | |
dc.identifier.issn | 1176-9114 (impreso) | es |
dc.identifier.issn | 1178-2013 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/98412 | |
dc.description.abstract | Background: Bacterial resistance to antibiotics is one of the biggest challenges facing medicine
today. Anti-adhesive therapy, using inhibitors of bacterial adhesion to epithelial cells, one of
the first stages of infection, is a promising approximation in this area. The size, shape, number
of sugar and their placement are variables that have to be taken into account in order to develop
multivalent systems able to inhibit the bacterial adhesion based on sugar-lectin interaction.
Materials and methods: In the present work we report a modular approach for the synthesis
of water-soluble 1D-carbon nanotube-sugar nanoconstructs, with the necessary flexibility to
allow an efficient sugar-lectin interaction. The method is based on the reaction of aryl diazonium
salts generated in situ from aniline-substituted mannose and lactose derivatives with single wall
carbon nanotubes (SWCNTs) sidewalls.
Results: Two hybrid nanosystems, I-II, exposing mannose or lactose and having a tetraethylene glycol spacer between the sugar and the nanotube sidewall were rapidly assembled and
adequately characterized. The sweet nano-objects were then tested for their ability to agglutinate and selectively inhibit the growth of uropathogenic Escherichia coli. These studies have
shown that nanosystem I, exposing mannose on the nanotube surface is able to agglutinate and
to inhibit the bacterial growth unlike nano-objects II exposing lactose.
Conclusion: The results reported constitute a proof of principle in using mannose-coated
1D-carbon nanotubes as antiadhesive drugs that compete for FimH binding and prevent the
uropathogenic bacteria from adhering to the urothelial surface. | es |
dc.description.sponsorship | Andalusian Government (FQM-313 to NK, BIO-026 to REW) | es |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness (CTQ2016-78580-C2-1-R to NK) | es |
dc.description.sponsorship | University of Seville (V PLAN PROPIO to REW) | es |
dc.description.sponsorship | European Regional Development Fund (FEDER) | es |
dc.format | application/pdf | es |
dc.format.extent | 19 p. | es |
dc.language.iso | eng | es |
dc.publisher | Dove Medical Press | es |
dc.relation.ispartof | International Journal of Nanomedicine, 14, 3245-3263. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Single-walled carbon nanotubes | es |
dc.subject | Carbohydrates | es |
dc.subject | Bacterial resistance | es |
dc.subject | Antiadhesive therapy | es |
dc.subject | Multivalency | es |
dc.subject | Aryl diazonium salts chemistry | es |
dc.title | Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | FQM-313 to NK | es |
dc.relation.projectID | BIO-026 to REW | es |
dc.relation.projectID | CTQ2016-78580-C2-1-R to NK | es |
dc.relation.publisherversion | http://dx.doi.org/10.2147/IJN.S179202 | es |
dc.identifier.doi | 10.2147/IJN.S179202 | es |
dc.journaltitle | International Journal of Nanomedicine | es |
dc.publication.volumen | 14 | es |
dc.publication.initialPage | 3245 | es |
dc.publication.endPage | 3263 | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Universidad de Sevilla | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |