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dc.creatorRomero Ben, Elenaes
dc.creatorCid, Juan Josées
dc.creatorAssali, Mohyeddines
dc.creatorFernández García, Elisabetes
dc.creatorWellinger, Ralf Erikes
dc.creatorKhiar, Noureddinees
dc.identifier.citationRomero Ben, E., Cid, J.J., Assali, M., Fernández García, E., Wellinger, R.E. y Khiar, N. (2019). Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination. International Journal of Nanomedicine, 14, 3245-3263.
dc.identifier.issn1176-9114 (impreso)es
dc.identifier.issn1178-2013 (electrónico)es
dc.description.abstractBackground: Bacterial resistance to antibiotics is one of the biggest challenges facing medicine today. Anti-adhesive therapy, using inhibitors of bacterial adhesion to epithelial cells, one of the first stages of infection, is a promising approximation in this area. The size, shape, number of sugar and their placement are variables that have to be taken into account in order to develop multivalent systems able to inhibit the bacterial adhesion based on sugar-lectin interaction. Materials and methods: In the present work we report a modular approach for the synthesis of water-soluble 1D-carbon nanotube-sugar nanoconstructs, with the necessary flexibility to allow an efficient sugar-lectin interaction. The method is based on the reaction of aryl diazonium salts generated in situ from aniline-substituted mannose and lactose derivatives with single wall carbon nanotubes (SWCNTs) sidewalls. Results: Two hybrid nanosystems, I-II, exposing mannose or lactose and having a tetraethylene glycol spacer between the sugar and the nanotube sidewall were rapidly assembled and adequately characterized. The sweet nano-objects were then tested for their ability to agglutinate and selectively inhibit the growth of uropathogenic Escherichia coli. These studies have shown that nanosystem I, exposing mannose on the nanotube surface is able to agglutinate and to inhibit the bacterial growth unlike nano-objects II exposing lactose. Conclusion: The results reported constitute a proof of principle in using mannose-coated 1D-carbon nanotubes as antiadhesive drugs that compete for FimH binding and prevent the uropathogenic bacteria from adhering to the urothelial
dc.description.sponsorshipAndalusian Government (FQM-313 to NK, BIO-026 to REW)es
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness (CTQ2016-78580-C2-1-R to NK)es
dc.description.sponsorshipUniversity of Seville (V PLAN PROPIO to REW)es
dc.description.sponsorshipEuropean Regional Development Fund (FEDER)es
dc.publisherDove Medical Presses
dc.relation.ispartofInternational Journal of Nanomedicine, 14, 3245-3263.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectSingle-walled carbon nanotubeses
dc.subjectBacterial resistancees
dc.subjectAntiadhesive therapyes
dc.subjectAryl diazonium salts chemistryes
dc.titleSurface modulation of single-walled carbon nanotubes for selective bacterial cell agglutinationes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.projectIDFQM-313 to NKes
dc.relation.projectIDBIO-026 to REWes
dc.relation.projectIDCTQ2016-78580-C2-1-R to NKes
dc.journaltitleInternational Journal of Nanomedicinees
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). Españaes
dc.contributor.funderUniversidad de Sevillaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional