dc.creator | Ávila Román, Francisco Javier | es |
dc.creator | Talero Barrientos, Elena Mª | es |
dc.creator | Rodríguez Luna, Azahara María | es |
dc.creator | García-Mauriño Ruiz-Berdejo, Sofía | es |
dc.date.accessioned | 2020-06-28T19:46:44Z | |
dc.date.available | 2020-06-28T19:46:44Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Ávila Román, F.J., Talero Barrientos, E.M., Rodríguez Luna, A.M. y García-Mauriño Ruiz-Berdejo, S. (2016). Anti-inflammatory effects of an oxylipin-containing lyophilised biomass from a microalga in a murine recurrent colitis model. British Journal of Nutrition, 116 (12), 2044-2052. | |
dc.identifier.issn | 1475-2662 | es |
dc.identifier.uri | https://hdl.handle.net/11441/98358 | |
dc.description.abstract | Diet and nutritional factors have emerged as possible interventions for inflammatory bowel diseases (IBD), which are characterised by chronic uncontrolled inflammation of the intestinal mucosa. Microalgal species are a promising source of n-3 PUFA and derived oxylipins, which are lipid mediators with a key role in the resolution of inflammation. The aim of the present study was to investigate the effects of an oxylipin-containing lyophilised biomass from Chlamydomonas debaryana on a recurrent 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis mice model. Moderate chronic inflammation of the colon was induced in BALB/c mice by weekly intracolonic instillations of low dose of TNBS. Administration of the lyophilised microalgal biomass started 2 weeks before colitis induction and was continued throughout colitis development. Mice were killed 48 h after the last TNBS challenge. Oral administration of the microalgal biomass reduced TNBS-induced intestinal inflammation, evidenced by an inhibition of body weight loss, an improvement in colon morphology and a decrease in pro-inflammatory cytokines TNF-α, IL-1β, IL-6 and IL-17. This product also down-regulated colonic expressions of inducible nitric oxide, cyclo-oxygenase 2 and NF-κB, as well as increased PPAR-γ. In addition, lyophilised microalgal biomass up-regulated the expressions of the antioxidant transcription factor nuclear factor E2-related factor 2 and the target gene heme oxygenase 1. This study describes for the first time the prophylactic effects of an oxylipin-containing lyophilised microalgae biomass from C. debaryana in the acute phase of a recurrent TNBS-induced colitis model in mice. These findings suggest the potential use of this microalga, or derived oxylipins, as a nutraceutical in the treatment of IBD. | es |
dc.description.sponsorship | España Ministerio de Economía y Competitividad MICIIN PSE-0632/0151 | es |
dc.description.sponsorship | España MICIIN INNPACTO-IPT-2012-1370-060000. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Cambridge University Press | es |
dc.relation.ispartof | British Journal of Nutrition, 116 (12), 2044-2052. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chlamydomonas debaryana | es |
dc.subject | Chronic inflammation | es |
dc.subject | Immune modulation | es |
dc.subject | Oxidative stress | es |
dc.subject | Pro-resolving lipid mediators | es |
dc.title | Anti-inflammatory effects of an oxylipin-containing lyophilised biomass from a microalga in a murine recurrent colitis model | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | MICIIN PSE-0632/0151 | es |
dc.relation.projectID | IPT-2012-1370-060000 | es |
dc.relation.publisherversion | https://doi.org/10.1017/S0007114516004189 | es |
dc.identifier.doi | 10.1017/S0007114516004189 | es |
dc.journaltitle | British Journal of Nutrition | es |
dc.publication.volumen | 116 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 2044 | es |
dc.publication.endPage | 2052 | es |