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dc.creatorÁvila Román, Francisco Javieres
dc.creatorTalero Barrientos, Elena Mªes
dc.creatorRodríguez Luna, Azahara Maríaes
dc.creatorGarcía-Mauriño Ruiz-Berdejo, Sofíaes
dc.identifier.citationÁvila Román, F.J., Talero Barrientos, E.M., Rodríguez Luna, A.M. y García-Mauriño Ruiz-Berdejo, S. (2016). Anti-inflammatory effects of an oxylipin-containing lyophilised biomass from a microalga in a murine recurrent colitis model. British Journal of Nutrition, 116 (12), 2044-2052.
dc.description.abstractDiet and nutritional factors have emerged as possible interventions for inflammatory bowel diseases (IBD), which are characterised by chronic uncontrolled inflammation of the intestinal mucosa. Microalgal species are a promising source of n-3 PUFA and derived oxylipins, which are lipid mediators with a key role in the resolution of inflammation. The aim of the present study was to investigate the effects of an oxylipin-containing lyophilised biomass from Chlamydomonas debaryana on a recurrent 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis mice model. Moderate chronic inflammation of the colon was induced in BALB/c mice by weekly intracolonic instillations of low dose of TNBS. Administration of the lyophilised microalgal biomass started 2 weeks before colitis induction and was continued throughout colitis development. Mice were killed 48 h after the last TNBS challenge. Oral administration of the microalgal biomass reduced TNBS-induced intestinal inflammation, evidenced by an inhibition of body weight loss, an improvement in colon morphology and a decrease in pro-inflammatory cytokines TNF-α, IL-1β, IL-6 and IL-17. This product also down-regulated colonic expressions of inducible nitric oxide, cyclo-oxygenase 2 and NF-κB, as well as increased PPAR-γ. In addition, lyophilised microalgal biomass up-regulated the expressions of the antioxidant transcription factor nuclear factor E2-related factor 2 and the target gene heme oxygenase 1. This study describes for the first time the prophylactic effects of an oxylipin-containing lyophilised microalgae biomass from C. debaryana in the acute phase of a recurrent TNBS-induced colitis model in mice. These findings suggest the potential use of this microalga, or derived oxylipins, as a nutraceutical in the treatment of
dc.description.sponsorshipEspaña Ministerio de Economía y Competitividad MICIIN PSE-0632/0151es
dc.description.sponsorshipEspaña MICIIN
dc.publisherCambridge University Presses
dc.relation.ispartofBritish Journal of Nutrition, 116 (12), 2044-2052.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectChlamydomonas debaryanaes
dc.subjectChronic inflammationes
dc.subjectImmune modulationes
dc.subjectOxidative stresses
dc.subjectPro-resolving lipid mediatorses
dc.titleAnti-inflammatory effects of an oxylipin-containing lyophilised biomass from a microalga in a murine recurrent colitis modeles
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.relation.projectIDMICIIN PSE-0632/0151es
dc.journaltitleBritish Journal of Nutritiones

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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