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Cytotoxic Activity of Microalgal-derived Oxylipins against Human Cancer Cell lines and their Impact on ATP Levels

dc.creatorÁvila Román, Francisco Javieres
dc.creatorTalero Barrientos, Elena Mªes
dc.creatorReyes, Carolina de loses
dc.creatorZubía, Evaes
dc.creatorMotilva Sánchez, Virginiaes
dc.creatorGarcía-Mauriño Ruiz-Berdejo, Sofíaes
dc.date.accessioned2020-06-28T19:46:11Z
dc.date.available2020-06-28T19:46:11Z
dc.date.issued2016
dc.identifier.citationÁvila Román, F.J., Talero Barrientos, E.M., Reyes, C.d.l., Zubía, E., Motilva Sánchez, V. y García-Mauriño Ruiz-Berdejo, S. (2016). Cytotoxic Activity of Microalgal-derived Oxylipins against Human Cancer Cell lines and their Impact on ATP Levels. Natural Product Communications, 11 (12), 1871-1875.
dc.identifier.issn1555-9475es
dc.identifier.urihttps://hdl.handle.net/11441/98357
dc.description.abstractOxylipins are metabolites derived from lipid peroxidation. The plant oxylipin methyl jasmonate (MJ) shows cytotoxic activity against cancer cell lines of various origins, with ATP-depletion being one of the mechanisms responsible for this effect. The cytotoxic activity of oxylipins (OXLs) isolated from the microalgae Chlamydomonas debaryana (13-HOTE) and Nannochloropsis gaditana (15-HEPE) was higher against UACC-62 (melanoma) than towards HT-29 (colon adenocarcinoma) cells. OXLs lowered the ATP levels of HT-29 and UACC-62 cells, but the effect was higher on the second cell line, which had higher basal ATP. This result proves a link between the cytotoxicity and the capability of these compounds to deplete ATP. In addition, the combination of 13-HOTE with the anticancer drug 5-fluorouracil (5-FU) induced a synergistic toxicity against HT-29 cells. These results highlight the therapeutic potential of oxylipins derived from microalgae.es
dc.description.sponsorshipEspaña MINECO and FEDER (research project IPT-2011-1370- 060000)es
dc.formatapplication/pdfes
dc.format.extent5 p.es
dc.language.isoenges
dc.publisherSAGE Publicationses
dc.relation.ispartofNatural Product Communications, 11 (12), 1871-1875.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChlamydomonas debaryanaes
dc.subjectNannochloropsis gaditanaes
dc.subjectATPes
dc.subjectCanceres
dc.subjectOxylipines
dc.subjectMethyl jasmonatees
dc.titleCytotoxic Activity of Microalgal-derived Oxylipins against Human Cancer Cell lines and their Impact on ATP Levelses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Vegetal y Ecologíaes
dc.relation.projectIDresearch project IPT-2011-1370- 060000es
dc.relation.publisherversionhttps://doi.org/10.1177/1934578X1601101225es
dc.identifier.doi10.1177/1934578X1601101225es
dc.journaltitleNatural Product Communicationses
dc.publication.volumen11es
dc.publication.issue12es
dc.publication.initialPage1871es
dc.publication.endPage1875es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). Españaes

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