dc.creator | Ávila Román, Francisco Javier | es |
dc.creator | Talero Barrientos, Elena Mª | es |
dc.creator | Reyes, Carolina de los | es |
dc.creator | Zubía, Eva | es |
dc.creator | Motilva Sánchez, Virginia | es |
dc.creator | García-Mauriño Ruiz-Berdejo, Sofía | es |
dc.date.accessioned | 2020-06-28T19:46:11Z | |
dc.date.available | 2020-06-28T19:46:11Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Ávila Román, F.J., Talero Barrientos, E.M., Reyes, C.d.l., Zubía, E., Motilva Sánchez, V. y García-Mauriño Ruiz-Berdejo, S. (2016). Cytotoxic Activity of Microalgal-derived Oxylipins against Human Cancer Cell lines and their Impact on ATP Levels. Natural Product Communications, 11 (12), 1871-1875. | |
dc.identifier.issn | 1555-9475 | es |
dc.identifier.uri | https://hdl.handle.net/11441/98357 | |
dc.description.abstract | Oxylipins are metabolites derived from lipid peroxidation. The plant oxylipin methyl jasmonate (MJ) shows cytotoxic activity against cancer cell lines of
various origins, with ATP-depletion being one of the mechanisms responsible for this effect. The cytotoxic activity of oxylipins (OXLs) isolated from the
microalgae Chlamydomonas debaryana (13-HOTE) and Nannochloropsis gaditana (15-HEPE) was higher against UACC-62 (melanoma) than towards HT-29
(colon adenocarcinoma) cells. OXLs lowered the ATP levels of HT-29 and UACC-62 cells, but the effect was higher on the second cell line, which had higher
basal ATP. This result proves a link between the cytotoxicity and the capability of these compounds to deplete ATP. In addition, the combination of 13-HOTE
with the anticancer drug 5-fluorouracil (5-FU) induced a synergistic toxicity against HT-29 cells. These results highlight the therapeutic potential of oxylipins
derived from microalgae. | es |
dc.description.sponsorship | España MINECO and FEDER (research project IPT-2011-1370- 060000) | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | SAGE Publications | es |
dc.relation.ispartof | Natural Product Communications, 11 (12), 1871-1875. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chlamydomonas debaryana | es |
dc.subject | Nannochloropsis gaditana | es |
dc.subject | ATP | es |
dc.subject | Cancer | es |
dc.subject | Oxylipin | es |
dc.subject | Methyl jasmonate | es |
dc.title | Cytotoxic Activity of Microalgal-derived Oxylipins against Human Cancer Cell lines and their Impact on ATP Levels | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Vegetal y Ecología | es |
dc.relation.projectID | research project IPT-2011-1370- 060000 | es |
dc.relation.publisherversion | https://doi.org/10.1177/1934578X1601101225 | es |
dc.identifier.doi | 10.1177/1934578X1601101225 | es |
dc.journaltitle | Natural Product Communications | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 1871 | es |
dc.publication.endPage | 1875 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |