dc.creator | Andrés, María C de | es |
dc.creator | Meiss, Mia S | es |
dc.creator | Sánchez Hidalgo, Marina | es |
dc.creator | González Benjumea, Alejandro | es |
dc.creator | Fernández-Bolaños Guzmán, José María | es |
dc.creator | Alarcón de la Lastra Romero, Catalina | es |
dc.creator | Oreffo, Richard OC | es |
dc.date.accessioned | 2020-06-23T21:00:12Z | |
dc.date.available | 2020-06-23T21:00:12Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Andrés, M.C.d., Meiss, M.S., Sánchez Hidalgo, M., González Benjumea, A., Fernández-Bolaños Guzmán, J.M., Alarcón de la Lastra Romero, C. y Oreffo, .O. (2020). Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol. Journal of Tissue Engineering, 11, 1-13. | |
dc.identifier.issn | 2041-7314 | es |
dc.identifier.uri | https://hdl.handle.net/11441/98173 | |
dc.description.abstract | Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, the immune system and chronic low-grade inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory potential and the capacity to attenuate cartilage degradation using extra-virgin olive oil–derived polyphenols for the treatment of osteoarthritis. Results show that both nutraceuticals ligstroside aglycone and acetylated ligstroside aglycone showed an anti-inflammatory profile. Acetylated ligstroside aglycone significantly reduced the expression of pro-inflammatory genes including NOS2 and MMP13 at both RNA and protein levels; decreased nitric oxide release; and, importantly, reduced proteoglycan loss in human osteoarthritis cartilage explants. Our study demonstrated that a new synthetic acetylated ligstroside aglycone derivative offers enhanced anti-inflammatory profile than the natural nutraceutical compound in osteoarthritis. These results substantiate the role of nutraceuticals in osteoarthritis with implications for therapeutic intervention and our understanding of osteoarthritis pathophysiology. | es |
dc.description.sponsorship | España, MINECO (CTQ2016-78703-P) | es |
dc.description.sponsorship | España, Junta de Andalucía (FQM134) | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Sage | es |
dc.relation.ispartof | Journal of Tissue Engineering, 11, 1-13. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cartilage | es |
dc.subject | osteoarthritis | es |
dc.subject | nutraceuticals | es |
dc.title | Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | FQM134 | es |
dc.relation.projectID | CTQ2016-78703-P | es |
dc.relation.publisherversion | http://dx.doi.org/ 10.1177/2041731420922701 | es |
dc.identifier.doi | 10.1177/2041731420922701 | es |
dc.journaltitle | Journal of Tissue Engineering | es |
dc.publication.volumen | 11 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 13 | es |