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dc.creatorAndrés, María C dees
dc.creatorMeiss, Mia Ses
dc.creatorSánchez Hidalgo, Marinaes
dc.creatorGonzález Benjumea, Alejandroes
dc.creatorFernández-Bolaños Guzmán, José Maríaes
dc.creatorAlarcón de la Lastra Romero, Catalinaes
dc.creatorOreffo, Richard OCes
dc.date.accessioned2020-06-23T21:00:12Z
dc.date.available2020-06-23T21:00:12Z
dc.date.issued2020
dc.identifier.citationAndrés, M.C.d., Meiss, M.S., Sánchez Hidalgo, M., González Benjumea, A., Fernández-Bolaños Guzmán, J.M., Alarcón de la Lastra Romero, C. y Oreffo, .O. (2020). Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol. Journal of Tissue Engineering, 11, 1-13.
dc.identifier.issn2041-7314es
dc.identifier.urihttps://hdl.handle.net/11441/98173
dc.description.abstractRecent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, the immune system and chronic low-grade inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory potential and the capacity to attenuate cartilage degradation using extra-virgin olive oil–derived polyphenols for the treatment of osteoarthritis. Results show that both nutraceuticals ligstroside aglycone and acetylated ligstroside aglycone showed an anti-inflammatory profile. Acetylated ligstroside aglycone significantly reduced the expression of pro-inflammatory genes including NOS2 and MMP13 at both RNA and protein levels; decreased nitric oxide release; and, importantly, reduced proteoglycan loss in human osteoarthritis cartilage explants. Our study demonstrated that a new synthetic acetylated ligstroside aglycone derivative offers enhanced anti-inflammatory profile than the natural nutraceutical compound in osteoarthritis. These results substantiate the role of nutraceuticals in osteoarthritis with implications for therapeutic intervention and our understanding of osteoarthritis pathophysiology.es
dc.description.sponsorshipEspaña, MINECO (CTQ2016-78703-P)es
dc.description.sponsorshipEspaña, Junta de Andalucía (FQM134)es
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherSagees
dc.relation.ispartofJournal of Tissue Engineering, 11, 1-13.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCartilagees
dc.subjectosteoarthritises
dc.subjectnutraceuticalses
dc.titleOsteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenoles
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDFQM134es
dc.relation.projectIDCTQ2016-78703-Pes
dc.relation.publisherversionhttp://dx.doi.org/ 10.1177/2041731420922701es
dc.identifier.doi10.1177/2041731420922701es
dc.journaltitleJournal of Tissue Engineeringes
dc.publication.volumen11es
dc.publication.initialPage1es
dc.publication.endPage13es

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