dc.creator | Blanco, Gonzalo | es |
dc.creator | Puiggros, Anna | es |
dc.creator | Baliakas, Panagiotis | es |
dc.creator | Athanasiadou, Anastasia | es |
dc.creator | Garca Malo, María Dolores | es |
dc.creator | Collado, Rosa | es |
dc.creator | Vargas de los Monteros, María Teresa | es |
dc.creator | Espinet, Blanca | es |
dc.date.accessioned | 2020-05-15T10:28:12Z | |
dc.date.available | 2020-05-15T10:28:12Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Blanco, G., Puiggros, A., Baliakas, P., Athanasiadou, A., Garca Malo, M.D., Collado, R.,...,Espinet, B. (2016). Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.. Oncotarget, 7 (49), 80916-80924. | |
dc.identifier.issn | 1949-2553. | es |
dc.identifier.uri | https://hdl.handle.net/11441/96744 | |
dc.description.abstract | Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations
(TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable
clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains
of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs www.impactjournals.com/oncotarget 80917 Oncotarget
However, the reported series were small, thus hindering definitive conclusions. To
gain insight into this issue, we assessed a series of 101 CLL patients harboring
TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively.
Both were associated with a significantly (P < 0.05) higher incidence of a complex
karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA)
compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate
analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK
(P = 0.009) were associated with shorter OS. However, in multivariate analysis only
CK (HR = 2.47, P = 0.027) maintained independent significance, being associated
with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our
results highlight the association of chromosome 8 abnormalities with CK amongst
CLL patients with TP53abs, while also revealing that CK can further aggravate the
prognosis of this aggressive subgroup. | es |
dc.description.sponsorship | Instituto Carlos III, Ministerio de Economía y Competitividad, Unión Europea PI11/01621, PI15/00437, RD09/0076/00036, RD12/0036/0044, RD12/0036/0069 and PT13/0010/0005 | es |
dc.description.sponsorship | Generalitat de Catalunya 2014/SGR585 | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language.iso | eng | es |
dc.publisher | Impact journals | es |
dc.relation.ispartof | Oncotarget, 7 (49), 80916-80924. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Karyotypic complexity. | es |
dc.subject | Chromosome 8 abnormalities. | es |
dc.subject | Lymphocytic leukemia. | es |
dc.subject | CLL. | es |
dc.subject | TP53 aberrations. | es |
dc.title | Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica. | es |
dc.identifier.doi | 10/18632/oncotarget 1310 | es |
dc.contributor.group | CTS-219: Servicio hematología y hemoterapia. Hospital Universitario Virgen del Rocío. | es |
dc.journaltitle | Oncotarget | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 49 | es |
dc.publication.initialPage | 80916 | es |
dc.publication.endPage | 80924 | es |