Artículo
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.
Autor/es | Blanco, Gonzalo
Puiggros, Anna Baliakas, Panagiotis Athanasiadou, Anastasia Garca Malo, María Dolores Collado, Rosa Vargas de los Monteros, María Teresa Espinet, Blanca |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica. |
Fecha de publicación | 2016 |
Fecha de depósito | 2020-05-15 |
Publicado en |
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Resumen | Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations
(TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable
clinical outcome. Chromosome 8 abnormalities, namely losses of ... Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs www.impactjournals.com/oncotarget 80917 Oncotarget However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup. |
Cita | Blanco, G., Puiggros, A., Baliakas, P., Athanasiadou, A., Garca Malo, M.D., Collado, R.,...,Espinet, B. (2016). Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.. Oncotarget, 7 (49), 80916-80924. |
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