dc.creator | Berrougui, Hicham | es |
dc.creator | Álvarez de Sotomayor Paz, María | es |
dc.creator | Pérez Guerrero, María Concepción | es |
dc.creator | Ettaib, Abdelkader | es |
dc.creator | Hmamouchi, Mohammed | es |
dc.creator | Marhuenda Requena, Elisa | es |
dc.creator | Herrera González, María Dolores | es |
dc.date.accessioned | 2020-05-14T15:07:23Z | |
dc.date.available | 2020-05-14T15:07:23Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Berrougui, H., Álvarez de Sotomayor Paz, M., Pérez Guerrero, M.C., Ettaib, A., Hmamouchi, M., Marhuenda Requena, E. y Herrera González, M.D. (2004). Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats. British Journal of Nutrition, 92 (6), 921-929. | |
dc.identifier.issn | 0007-1145 | es |
dc.identifier.issn | 1475-2662 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96708 | |
dc.description.abstract | Traditionally hand-pressed argan oil, obtained from Argania spinosa seeds, is eaten raw in south-west Morocco; its rich composition of tocopherols, MUFA and PUFA make a study of its actions on risk factors for CVD, such as hypertension, interesting. The effects of 7 weeks of treatment with argan oil (10 ml/kg) on the blood pressure and endothelial function of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats were investigated. Systolic blood pressure and heart rate were measured every week by the tailcuff method and endothelial function was assessed by carbachol (10-8 to 10-4M -induced relaxations of aortic rings and small mesenteric arteries pre-contracted with phenylephrine. Argan-oil administration reduced the mean blood pressure of SHR after the fifth week of treatment (P<0.05) and increased (P<0.01) the endothelial responses of arteries from SHR. The NO synthase inhibitor, L-N-ω-nitroarginine (3 × 10-5M) revealed a greater participation of NO in the relaxant effect after the treatment. When cyclooxygenase (COX) was blocked with indomethacin (10-5M), an involvement of COX products in the endothelium-dependent response was characterized. Enzyme immunoassay of thromboxane B2 showed a significant decrease (P< 0.05) in the release of thromboxane A2 in both aorta and small mesenteric artery after argan-oil treatment of SHR. Experiments in the presence of the thromboxane A2-prostaglandin H2 receptor antagonist ICI 192,605 (10-5M) confirmed this result. Results after incubation with the antioxidants superoxide dismutase and catalase suggested that a decreased oxidative stress might contribute to explain the beneficial effects of argan-oil treatment. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Cambridge University Press | es |
dc.relation.ispartof | British Journal of Nutrition, 92 (6), 921-929. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Argan oil | es |
dc.subject | Cyclooxygenase products | es |
dc.subject | Endothelium | es |
dc.subject | Hypertension | es |
dc.subject | Spontaneously hypertensive rats | es |
dc.title | Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.publisherversion | http://dx.doi.org/10.1079/BJN20041293 | es |
dc.identifier.doi | 10.1079/BJN20041293 | es |
dc.journaltitle | British Journal of Nutrition | es |
dc.publication.volumen | 92 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 921 | es |
dc.publication.endPage | 929 | es |