dc.creator | Vila-Farrés, Xavier | es |
dc.creator | Parra Millán, Raquel | es |
dc.creator | Sánchez-Encinales, Viviana | es |
dc.creator | Varese, Mónica | es |
dc.creator | Ayerbe Algaba, Rafael | es |
dc.creator | Bayó, Nuria | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.creator | Smani, Younes | es |
dc.date.accessioned | 2020-05-14T11:02:32Z | |
dc.date.available | 2020-05-14T11:02:32Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Vila-Farrés, X., Parra Millán, R., Sánchez-Encinales, V., Varese, M., Ayerbe Algaba, R., Bayó, N.,...,Smani, Y. (2017). Combating virulence of Gramnegative bacilli by OmpA inhibition. Scientific Reports, 7 (14683), 1-11. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96668 | |
dc.description.abstract | Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling
multidrug-resistant bacteria. In this regard, the identifcation of outer membrane protein A (OmpA)
as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped
us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii,
Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of bioflm, thereby
preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of
OmpA ofers a strategy as monotherapy to address the urgent need for treatments for infections caused
by Gram-negative bacilli. | es |
dc.description.sponsorship | Instituto de Salud Carlos III, Ministerio de Economía y Competitividad REIPI RD12/0015/0001 | es |
dc.description.sponsorship | Unión Europea ES P201431400 | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad CP15/01358 | es |
dc.description.sponsorship | Junta de Andalucía CTS-6173/12 y 2014LLAV-00064 | es |
dc.description.sponsorship | Junta de Andalucía PI12–0069 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.relation.ispartof | Scientific Reports, 7 (14683), 1-11. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | E. coli | es |
dc.subject | Treatments for infections | es |
dc.subject | Inhibition | es |
dc.title | Combating virulence of Gramnegative bacilli by OmpA inhibition | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.identifier.doi | 10.1038/s41598-017-14972-y | es |
dc.contributor.group | Universidad de Sevilla. CTS-203: Estudio de las Enfermedades Infecciosas | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 14683 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 11 | es |