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dc.creatorNeukam, Karines
dc.creatorMilanés Guisado, Yusnelkises
dc.creatorFontillón, Maríaes
dc.creatorMerino, Lauraes
dc.creatorSotomayor, Césares
dc.creatorEspinosa, Nuriaes
dc.creatorLópez Cortés, Luis Fernandoes
dc.creatorViciana Fernández, Pompeyoes
dc.date.accessioned2020-05-12T11:10:37Z
dc.date.available2020-05-12T11:10:37Z
dc.date.issued2019
dc.identifier.citationNeukam, K., Milanés Guisado, Y., Fontillón, M., Merino, L., Sotomayor, C., Espinosa, N.,...,Viciana Fernández, P. (2019). High-resolution anoscopy in HIV-infected men: Assessment of the learning curve and factors that improve the performance. Papillomavirus Research, 7, 62-66.
dc.identifier.issn2405-8521es
dc.identifier.urihttps://hdl.handle.net/11441/96467
dc.description.abstractTo determine the required learning time for high-resolution anoscopy (HRA)-guided biopsy to detect histological high-risk squamous intraepithelial lesions (hHSIL) and to identify factors that impact on the training process. Methods: All HIV-infected, screening-naïve men-who-have-sex-with-men who underwent HRA conducted by one single observer from 2010 to 2017 in a Spanish HIV-outpatient clinic were analysed. Results: Eighty-five (14.7%) of the 581 patients included presented hHSIL. The factors associated with the capacity to detect hHSIL [adjusted odds ratio (aOR), 95% confidence interval (95%CI)] were the presence of cytological HSIL (3.04, 1.78–5.21; p < 0.001), infection with high-risk human papilloma virus (HR-HPV) (2.89, 1.38–6.05; p=0.005), the number of biopsies taken/HRA (aOR: 1.28, 1.07–1.52; p=0.006) and tobacco smoking (1.75; 1.12–2.73; p=0.014). Two events independently augmented the detection rate of hHSIL: one single experienced pathologist interpreted biopsies after 409 HRA (2.80, 1.74–4.48; p=0.035) and the anoscopist underwent an additional training after 536 HRA (2.57, 1.07–6.16; p=0.035). A learning process could be observed throughout the whole study with stable HR-HPV prevalence. Conclusion: The data support the growing evidence that the proposed training volume of 50–200 performances is underestimated. Extensive training of both anoscopist and pathologist is warranted and the development of tools to support the diagnostic performance may be considered.es
dc.description.sponsorshipPlan Nacional R+D+I y Red de Investigación en SIDA RD16/0025/0020-ISCIII-FEDes
dc.description.sponsorshipMiguel Servet research grant, Instituto de Salud Carlos III CPII18/00033es
dc.formatapplication/pdfes
dc.format.extent5es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofPapillomavirus Research, 7, 62-66.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHigh-resolution anoscopy,es
dc.subjectHuman papillomaviruses
dc.subjectAnal squamous cell carcinomaes
dc.subjectOperator experiencees
dc.subjectLearning curvees
dc.subjectLiquid-based cytologyes
dc.titleHigh-resolution anoscopy in HIV-infected men: Assessment of the learning curve and factors that improve the performancees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.date.embargoEndDate2021-05
dc.identifier.doi10-1016/j.pvr.2019.01.003es
dc.contributor.groupUniversidad de Sevilla. CTS203: Estudio enfermedades infecciosas.es
dc.journaltitlePapillomavirus Researches
dc.publication.volumen7es
dc.publication.initialPage62es
dc.publication.endPage66es

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