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dc.creatorJiménez, Davides
dc.creatorAgustí, Alvares
dc.creatorMonreal, Manueles
dc.creatorOtero Candelera, Remedioses
dc.creatorHuisman, Menno V.es
dc.creatorLobo, José L.es
dc.creatorYusen, Rogeres
dc.date.accessioned2020-05-05T10:26:01Z
dc.date.available2020-05-05T10:26:01Z
dc.date.issued2019-02-25
dc.identifier.issn1932-8737es
dc.identifier.urihttps://hdl.handle.net/11441/96139
dc.description.abstractIntroduction: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs usual care) in patients hospitalized because of ECOPD. Methods: SLICE is a phase III, prospective, international, multicenter, randomized, open-label, and parallel-group trial. A total of 746 patients hospitalized because of ECOPD will be random- ized in a 1:1 fashion to receive either an active strategy for the diagnosis and anticoagulant treatment of PE or usual care (ie, standard care without any diagnostic test for diagnosing PE). The primary outcome is a composite of all-cause death, non-fatal (recurrent) venous thrombo- embolism (VTE), or readmission for ECOPD within 90 days after enrollment. Secondary out- comes are (a) death from any cause within 90 days after enrollment, (b) non-fatal (recurrent) VTE within 90 days after enrollment, (c) readmission within 90 days after enrollment, and (d) length of hospital stay. Results: Enrollment started in September 2014 and is expected to proceed until 2020. Median age of the first 443 patients was 71 years (interquartile range, 64-78), and 26% were female. Conclusions: This multicenter trial will determine the value of detecting PEs in patients with ECOPD. This has implications for COPD patient morbidity and mortality.es
dc.description.sponsorshipMinisterio de Salud, Instituto de Salud Carlos III: PI14/00400es
dc.formatapplication/pdfes
dc.format.extent6es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChronic obstructive pulmonary diseasees
dc.subjectExacerbationes
dc.subjectPulmonary embolismes
dc.subjectTreatmentes
dc.titleThe rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy and safety of an active strategy for the diagnosis and treatment of acute pulmonary embolism during exacerbations of chronic obstructive pulmonary disease.es
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.identifier.doi10.1002/clc.23161es
dc.journaltitleClinical Cardiologyes
dc.publication.volumen42es
dc.publication.issue3es
dc.publication.initialPage346es
dc.publication.endPage351es

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