dc.creator | Cosío, Borja G. | es |
dc.creator | Soriano, Joan B. | es |
dc.creator | López-Campos Bodineau, José Luis | es |
dc.creator | Calle, Myriam | es |
dc.creator | Soler, Juan José | es |
dc.creator | Torres, Juan Pablo de | es |
dc.creator | Alfageme Michavila, Inmaculada | es |
dc.date.accessioned | 2020-04-30T12:03:29Z | |
dc.date.available | 2020-04-30T12:03:29Z | |
dc.date.issued | 2016-11-02 | |
dc.identifier.citation | Cosío, B.G., Soriano, J.B., López-Campos Bodineau, J.L., Calle, M., Soler, J.J., Torres, J.P.d. y Alfageme Michavila, I. (2016). Distribution and Outcomes of a Phenotype- Based Approach to Guide COPD Management: Results from the CHAIN Cohort. Plos One, 11 (11) | |
dc.identifier.issn | 1932-6203 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96043 | |
dc.description.abstract | Rationale The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to
four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphy-
sema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with
emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). How-
ever, little is known on the distribution and outcomes of the four suggested phenotypes.
Objective
We aimed to determine the distribution of these COPD phenotypes, and their relation with
one-year clinical outcomes.
Methods
We followed a cohort of well-characterized patients with COPD up to one-year. Baseline
characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to
one year of follow-up were compared between the four phenotypes.
Results
Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550
(66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19
(2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE
nor FECB. At baseline, there were significant differences in symptoms, FEV 1 and BODE
index (all p<0.05). The FECB phenotype had the highest CAT score (17.1±8.2, p<0.05
compared to the other phenotypes). Frequent exacerbator groups (FEE and FECB) were
receiving more pharmacological treatment at baseline, and also experienced more exacer-
bations the year after (all p<0.05) with no differences in one-year mortality. Most of NE
(93%) and half of exacerbators were stable after one year.
Conclusions
There is an uneven distribution of COPD phenotypes in stable COPD patients, with signifi-
cant differences in demographics, patient-centered outcomes and health care resources
use. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 | es |
dc.language.iso | eng | es |
dc.publisher | Public Library Of Science. | es |
dc.relation.ispartof | Plos One, 11 (11) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Phenotype | es |
dc.subject | The Spanish guideline for COPD | es |
dc.subject | Asthma-COPD | es |
dc.subject | Chronic bronchitis | es |
dc.title | Distribution and Outcomes of a Phenotype- Based Approach to Guide COPD Management: Results from the CHAIN Cohort | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.identifier.doi | 10.1371/journal.pone.0160770 | es |
dc.journaltitle | Plos One | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 11 | es |