dc.creator | Jiménez Jorge, Silvia | es |
dc.creator | Palacios Baena, Zaira Raquel | es |
dc.creator | Rosso Fernández, Clara | es |
dc.creator | Girón Ortega, José A. | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Retamar Gentil, Pilar | es |
dc.date.accessioned | 2020-04-29T18:04:16Z | |
dc.date.available | 2020-04-29T18:04:16Z | |
dc.date.issued | 2018-12-18 | |
dc.identifier.citation | Jiménez Jorge, S., Palacios Baena, Z.R., Rosso Fernández, C., Girón Ortega, .A., Rodriguez Baño, J. y Retamar Gentil, P. (2018). Opportunities for antibiotic optimisation and outcome improvement in patients with negative blood cultures: study protocol for a cluster-randomised crossover trial, the NO-BACT study.. BMJ Open, 9 (12) | |
dc.identifier.issn | 2044-6055 | es |
dc.identifier.uri | https://hdl.handle.net/11441/95993 | |
dc.description.abstract | Introduction Patients with negative blood cultures (BCx)
represent 85%–90% of all patients with BCx taken during
hospital admission. This population usually includes a
heterogeneous group of patients admitted with infectious
diseases or febrile syndromes that require a blood culture.
There is very little evidence of the clinical characteristics
and antibiotic treatment given to these patients.
Methods and analysis In a preliminary exploratory
prospective cohort study of patients with BCx taken,
the clinical/therapeutic characteristics and outcomes/
antimicrobial stewardship opportunities of a population of
patients with negative BCx will be analysed. In the second
phase, using a cluster randomised crossover design,
the implementation of an antimicrobial stewardship
intervention targeting patients with negative BCx will be
evaluated in terms of quality of antimicrobial use (duration
and de-escalation), length of hospital stay and mortality.
Ethics and dissemination This study has been and
registered with clinicaltrials.gov. The findings of our study
may support the implementation in clinical practice of an
antimicrobial stewardship intervention to optimise the use
of antibiotics in patients with negative BCx. The results of
this study will be published in peer-reviewed journals and
disseminated at national and international conferences.
Trial registration number NCT03535324. | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI17 / 01809 | es |
dc.description.sponsorship | Plataforma Española de Investigación Clínica y Ensayos Clínicos, SCReN (Red Española de Investigación Clínica), financiada por la Subdirección General de Evaluación y Promoción de la Investigación ISCIII: PT17 / 0017/0012. Cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | BMJ Open, 9 (12) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | BCx | es |
dc.subject | Antibiotic | es |
dc.subject | Negative blood cultures | es |
dc.title | Opportunities for antibiotic optimisation and outcome improvement in patients with negative blood cultures: study protocol for a cluster-randomised crossover trial, the NO-BACT study. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.identifier.doi | 10.1136/bmjopen-2019-030062 | es |
dc.contributor.group | Universidad de Sevilla. CTS406: Estudio de enfermedades infecciosas en la práctica clínica | es |
dc.journaltitle | BMJ Open | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 12 | es |