dc.creator | Roca Oporto, Cristina | es |
dc.creator | Cebrero Cangueiro, Tania | es |
dc.creator | Gil Marqués, María Luisa | es |
dc.creator | Labrador Herrera, Gema | es |
dc.creator | Smani, Younes | es |
dc.creator | González Roncero, Francisco Manuel | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.creator | Pachón Ibáñez, María Eugenia | es |
dc.creator | Cordero Matia, María Elisa | es |
dc.date.accessioned | 2020-04-29T17:38:44Z | |
dc.date.available | 2020-04-29T17:38:44Z | |
dc.date.issued | 2019-08-06 | |
dc.identifier.citation | Roca Oporto, C., Cebrero Cangueiro, T., Gil Marqués, M.L., Labrador Herrera, G., Smani, Y., González Roncero, F.M.,...,Cordero Matia, M.E. (2019). Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients. BMC Infectious diseases, 19 | |
dc.identifier.issn | 1471-2334 | es |
dc.identifier.uri | https://hdl.handle.net/11441/95992 | |
dc.description.abstract | Background: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant
recipient (SOTR); nevertheless, the prevalence of colonization and of the colonizing/infecting serotypes has not
been studied in this population. In this context, the aim of the present study was to describe the rate,
characteristics, and clinical impact of S. pneumoniae nasopharyngeal carriage.
Methods: A prospective observational cohort of Solid Organ Transplant recipients (SOTR) was held at the University
Hospital Virgen del Rocío, Seville, Spain with the aim to evaluate the S. pneumoniae colonization and the serotype
prevalence in SOTR. Two different pharyngeal swabs samples from 500 patients were included in two different
seasonal periods winter and spring/summer. Optochin and bile solubility tests were performed for the isolation of
thew strains. Antimicrobial susceptibility studies (MICs, mg/l) of levofloxacin, trimethoprim-sulfamethoxazole,
penicillin, amoxicillin, cefotaxime, ceftriaxone, erythromycin, azithromycin and vancomycin for each isolate were
determined by E-test strips. Capsular typing was done by sequential multiplex PCR reactions. A multivariate logistic
regression analysis of factors potentially associated with pneumococcal nasopharyngeal carriage and disease was
performed.
Results: Twenty-six (5.6%) and fifteen (3.2%) patients were colonized in winter and spring/summer periods,
respectively. Colonized SOT recipients compared to non-colonized patients were more frequently men (79.5% vs.
63.1%, P < 0.05) and cohabitated regularly with children (59% vs. 32.2%, P < 0.001). The most prevalent serotype in
both studied periods was 35B. Forty-five percent of total isolates were included in the pneumococcal vaccine
PPV23. Trimethoprim-sulfamethoxazole and macrolides were the less active antibiotics. Three patients had non-
bacteremic pneumococcal pneumonia, and two of them died.
Conclusions: Pneumococcal colonization in SOTR is low with the most colonizing serotypes not included in the
pneumococcal vaccines. | es |
dc.description.sponsorship | Pfizer, 2014 ASPIRE Awards in Vaccine Research in Europe (Pfizer Reference # WI191483) | es |
dc.description.sponsorship | Plan Nacional de I + D + i 2013–2016 , Instituto de Salud Carlos III,
Ministerio de Economía, Industria y Competitividad REIPI RD16/0016/0009
Fondo Regional de Desarrollo Europeo "Una forma de alcanzar Europa", Programa operativo Crecimiento inteligente 2014–2020. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | BMC Infectious diseases, 19 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Nasopharyngeal carriage | es |
dc.subject | Streptococcus pneumoniae | es |
dc.subject | Solid organ transplant recipients | es |
dc.title | Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.identifier.doi | 10.1186/s12879-019-4321-8 | es |
dc.contributor.group | Universidad de Sevilla. CTS203: Estudio de enfermedades infecciosas. | es |
dc.journaltitle | BMC Infectious diseases | es |
dc.publication.volumen | 19 | es |