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dc.creatorRoca Oporto, Cristinaes
dc.creatorCebrero Cangueiro, Taniaes
dc.creatorGil Marqués, María Luisaes
dc.creatorLabrador Herrera, Gemaes
dc.creatorSmani, Youneses
dc.creatorGonzález Roncero, Francisco Manueles
dc.creatorPachón Díaz, Jerónimoes
dc.creatorPachón Ibáñez, María Eugeniaes
dc.creatorCordero Matia, María Elisaes
dc.date.accessioned2020-04-29T17:38:44Z
dc.date.available2020-04-29T17:38:44Z
dc.date.issued2019-08-06
dc.identifier.citationRoca Oporto, C., Cebrero Cangueiro, T., Gil Marqués, M.L., Labrador Herrera, G., Smani, Y., González Roncero, F.M.,...,Cordero Matia, M.E. (2019). Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients. BMC Infectious diseases, 19
dc.identifier.issn1471-2334es
dc.identifier.urihttps://hdl.handle.net/11441/95992
dc.description.abstractBackground: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient (SOTR); nevertheless, the prevalence of colonization and of the colonizing/infecting serotypes has not been studied in this population. In this context, the aim of the present study was to describe the rate, characteristics, and clinical impact of S. pneumoniae nasopharyngeal carriage. Methods: A prospective observational cohort of Solid Organ Transplant recipients (SOTR) was held at the University Hospital Virgen del Rocío, Seville, Spain with the aim to evaluate the S. pneumoniae colonization and the serotype prevalence in SOTR. Two different pharyngeal swabs samples from 500 patients were included in two different seasonal periods winter and spring/summer. Optochin and bile solubility tests were performed for the isolation of thew strains. Antimicrobial susceptibility studies (MICs, mg/l) of levofloxacin, trimethoprim-sulfamethoxazole, penicillin, amoxicillin, cefotaxime, ceftriaxone, erythromycin, azithromycin and vancomycin for each isolate were determined by E-test strips. Capsular typing was done by sequential multiplex PCR reactions. A multivariate logistic regression analysis of factors potentially associated with pneumococcal nasopharyngeal carriage and disease was performed. Results: Twenty-six (5.6%) and fifteen (3.2%) patients were colonized in winter and spring/summer periods, respectively. Colonized SOT recipients compared to non-colonized patients were more frequently men (79.5% vs. 63.1%, P < 0.05) and cohabitated regularly with children (59% vs. 32.2%, P < 0.001). The most prevalent serotype in both studied periods was 35B. Forty-five percent of total isolates were included in the pneumococcal vaccine PPV23. Trimethoprim-sulfamethoxazole and macrolides were the less active antibiotics. Three patients had non- bacteremic pneumococcal pneumonia, and two of them died. Conclusions: Pneumococcal colonization in SOTR is low with the most colonizing serotypes not included in the pneumococcal vaccines.es
dc.description.sponsorshipPfizer, 2014 ASPIRE Awards in Vaccine Research in Europe (Pfizer Reference # WI191483)es
dc.description.sponsorshipPlan Nacional de I + D + i 2013–2016 , Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad REIPI RD16/0016/0009 Fondo Regional de Desarrollo Europeo "Una forma de alcanzar Europa", Programa operativo Crecimiento inteligente 2014–2020.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.language.isoenges
dc.relation.ispartofBMC Infectious diseases, 19
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNasopharyngeal carriagees
dc.subjectStreptococcus pneumoniaees
dc.subjectSolid organ transplant recipientses
dc.titlePrevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipientses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.identifier.doi10.1186/s12879-019-4321-8es
dc.contributor.groupUniversidad de Sevilla. CTS203: Estudio de enfermedades infecciosas.es
dc.journaltitleBMC Infectious diseaseses
dc.publication.volumen19es

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