dc.creator | Gudiol, C | es |
dc.creator | Royo Cebrecos, C | es |
dc.creator | Tebe, C | es |
dc.creator | Abdala, M | es |
dc.creator | Akova, M | es |
dc.creator | Álvarez Marín, Rocío | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.date.accessioned | 2020-04-29T10:41:05Z | |
dc.date.available | 2020-04-29T10:41:05Z | |
dc.date.issued | 2017-01-23 | |
dc.identifier.citation | Gudiol, C., Royo Cebrecos, C., Tebe, C., Abdala, M., Akova, M., Álvarez Marín, R. y Rodriguez Baño, J. (2017). Clinical efficacy of β-lactam/β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum β-lactamase- producing Enterobacteriaceae in haematological patients with neutropaenia: a study protocol for a retrospect observational study (BICAR).. BMJ Open, 7 (1) | |
dc.identifier.issn | 2044-6055 | es |
dc.identifier.uri | https://hdl.handle.net/11441/95952 | |
dc.description.abstract | Introduction: Bloodstream infection (BSI) due to
extended-spectrum β-lactamase-producing Gram-
negative bacilli (ESBL-GNB) is increasing at an
alarming pace worldwide. Although β-lactam/β-
lactamase inhibitor (BLBLI) combinations have been
suggested as an alternative to carbapenems for the
treatment of BSI due to these resistant organisms in
the general population, their usefulness for the
treatment of BSI due to ESBL-GNB in haematological
patients with neutropaenia is yet to be elucidated. The
aim of the BICAR study is to compare the efficacy of
BLBLI combinations with that of carbapenems for the
treatment of BSI due to an ESBL-GNB in this
population.
Methods and analysis: A multinational, multicentre,
observational retrospective study. Episodes of BSI due
to ESBL-GNB occurring in haematological patients and
haematopoietic stem cell transplant recipients with
neutropaenia from 1 January 2006 to 31 March 2015
will be analysed. The primary end point will be case-
fatality rate within 30 days of onset of BSI. The
secondary end points will be 7-day and 14-day case-
fatality rates, microbiological failure, colonisation/
infection by resistant bacteria, superinfection, intensive
care unit admission and development of adverse events.
Sample size: The number of expected episodes of BSI
due to ESBL-GNB in the participant centres will be 260
with a ratio of control to experimental participants of 2.
Ethics and dissemination: The protocol of the
study was approved at the first site by the Research
Ethics Committee (REC) of Hospital Universitari de
Bellvitge. Approval will be also sought from all relevant
RECs. Any formal presentation or publication of data
from this study will be considered as a joint
publication by the participating investigators and will
follow the recommendations of the International
Committee of Medical Journal Editors (ICMJE). The
study has been endorsed by the European Study Group
for Bloodstream Infection and Sepsis (ESGBIS) and the
European Study Group for Infections in Compromised
Hosts (ESGICH). | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad REIPI RD12/0015 | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | BMJ Open, 7 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | β-lactam/β- lactamase inhibitor | es |
dc.subject | β-lactamase-producing Gram- negative bacilli | es |
dc.subject | Bloodstream infection | es |
dc.title | Clinical efficacy of β-lactam/β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum β-lactamase- producing Enterobacteriaceae in haematological patients with neutropaenia: a study protocol for a retrospect observational study (BICAR) | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.identifier.doi | 10.1136/bmjopen-2016-013268 | es |
dc.contributor.group | Universidad de Sevilla. CTS 406: Estudio enfermedades infecciosas en la práctica clínica | es |
dc.journaltitle | BMJ Open | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 1 | es |
dc.identifier.sisius | 7799 | es |