dc.creator | Zbakh, Hanaa | es |
dc.creator | Zubía, Eva | es |
dc.creator | Reyes, Carolina de los | es |
dc.creator | Calderón Montaño, José Manuel | es |
dc.creator | López Lázaro, Miguel | es |
dc.creator | Motilva Sánchez, Virginia | es |
dc.date.accessioned | 2020-04-16T10:40:23Z | |
dc.date.available | 2020-04-16T10:40:23Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Zbakh, H., Zubía, E., Reyes, C.d.l., Calderón Montaño, J.M., López Lázaro, M. y Motilva Sánchez, V. (2020). Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents. Marine Drugs, 18 (4), 1-16. | |
dc.identifier.issn | 1660-3397 | es |
dc.identifier.uri | https://hdl.handle.net/11441/95307 | |
dc.description.abstract | The anti-inflammatory and anticancer properties of eight meroterpenoids isolated from the brown seaweed Cystoseira usneoides have been evaluated. The algal meroterpenoids (AMTs) 1-8 were tested for their inhibitory effects on the production of the pro-inflammatory cytokines tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), and the expression of cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in LPS-stimulated THP-1 human macrophages. The anticancer effects were assessed by cytotoxicity assays against human lung adenocarcinoma A549 cells and normal lung fibroblastic MRC-5 cells, together with flow cytometry analysis of the effects of these AMTs on different phases of the cell cycle. The AMTs 1-8 significantly reduced the production of TNF-α, IL-6, and IL-1β, and suppressed the COX-2 and iNOS expression, in LPS-stimulated cells (p < 0.05). The AMTs 1-8 displayed higher cytotoxic activities against A549 cancer cells than against MRC-5 normal lung cells. Cell cycle analyses indicated that most of the AMTs caused the arrest of A549 cells at the G2/M and S phases. The AMTs 2 and 5 stand out by combining significant anti-inflammatory and anticancer activities, while 3 and 4 showed interesting selective anticancer effects. These findings suggest that the AMTs produced by C. usneoides may have therapeutic potential in inflammatory diseases and lung cancer. | es |
dc.description.sponsorship | España Junta de Andalucía (Research project P12-AGR-430) | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Marine Drugs, 18 (4), 1-16. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cystoseira usneoides | es |
dc.subject | cell cycle | es |
dc.subject | cytokines | es |
dc.subject | inflammation | es |
dc.subject | lung cancer | es |
dc.subject | meroterpenoids | es |
dc.title | Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | Research project P12-AGR-430 | es |
dc.relation.publisherversion | https://doi.org/10.3390/md18040207 | es |
dc.identifier.doi | 10.3390/md18040207 | es |
dc.journaltitle | Marine Drugs | es |
dc.publication.volumen | 18 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 16 | es |
dc.contributor.funder | Junta de Andalucía | es |