dc.creator | Lemus Conejo, Ana | es |
dc.creator | Grao Cruces, Elena | es |
dc.creator | Toscano, Rocío | es |
dc.creator | Varela Pérez, Lourdes María | es |
dc.creator | Claro Cala, Carmen María | es |
dc.creator | Pedroche, Justo | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.creator | Millán, Francisco | es |
dc.date.accessioned | 2020-04-15T08:56:20Z | |
dc.date.available | 2020-04-15T08:56:20Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Lemus Conejo, A., Grao Cruces, E., Toscano, R., Varela Pérez, L.M., Claro Cala, C.M., Pedroche, J.,...,Millán, F. (2020). A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice. Food and Function, 11 (4), 2943-2952. | |
dc.identifier.issn | 2042-650X | es |
dc.identifier.uri | https://hdl.handle.net/11441/95216 | |
dc.description.abstract | Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg-1 day-1 or 1 mg kg-1 day-1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Food and Function, 11 (4), 2943-2952. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | http://dx.doi.org/10.1039/d0fo00206b | es |
dc.identifier.doi | 10.1039/d0fo00206b | es |
dc.journaltitle | Food and Function | es |
dc.publication.volumen | 11 | |
dc.publication.issue | 4 | |
dc.publication.initialPage | 2943 | es |
dc.publication.endPage | 2952 | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |