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dc.creatorToro Estévez, Raquel deles
dc.creatorChevre, Raphaeles
dc.creatorRodríguez, Cristinaes
dc.creatorOrdoñez, Antonioes
dc.creatorMartinez Gonzalez, Josées
dc.creatorAndrés, Vicentees
dc.creatorMéndez Ferrer, Simónes
dc.date.accessioned2020-03-31T08:48:44Z
dc.date.available2020-03-31T08:48:44Z
dc.date.issued2016-09-02
dc.identifier.citationToro Estévez, R.d., Chevre, R., Rodríguez, C., Ordoñez, A., Martinez Gonzalez, J., Andrés, V. y Méndez Ferrer, S. (2016). Nestinþ cells direct inflammatory cell migration in atherosclerosis. Nature communications, 7, 1-12.
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/94716
dc.description.abstractAtherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestinþ cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestinþ cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestinþ cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestinþ cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestinþ stromal cells increase B30 times and contribute to the atheroma plaque. Mcp1 deletion in nestinþ cells—but not in endothelial cells only— increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis.es
dc.description.sponsorshipPro-CNIC Foundationes
dc.description.sponsorshipSevero Ochoa Center of Excellence award SEV-2015-0505 to CNICes
dc.description.sponsorshipWellcome Trust and MRC to the Cambridge Stem Cell Institutees
dc.description.sponsorshipMinisterio de Economía y Competitividad (RETIC Grant RD12/0042/0028 to V.A.; SAF2012-40127 to J.M-G.; Plan Nacional Grant SAF-2011-30308, Ramón y Cajal Program Grant RYC-2009-04703 and Spanish Cell Therapy Network TerCel to S.M-F.)es
dc.description.sponsorshipMarie Curie Career Integration Program Grant (FP7-PEOPLE-2011-294096)es
dc.description.sponsorshipConSEPOC-Comunidad de Madrid Grant (S2010/BMD-2542)es
dc.description.sponsorshipNational Health Institute Blood and Transplant (United Kingdom)es
dc.description.sponsorshipHorizon2020 (ERC-2014-CoG-64765)es
dc.description.sponsorshipHorizon2020 (ERC-2014-CoG-64765)es
dc.formatapplication/pdfes
dc.format.extent12es
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relation.ispartofNature communications, 7, 1-12.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAtherosclerosises
dc.subjectNestinþ cellses
dc.subjectInflammatory cell migrationes
dc.titleNestinþ cells direct inflammatory cell migration in atherosclerosises
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationInstituto de Biomedicina de Sevillaes
dc.identifier.doi101038/nc comms 12706es
dc.journaltitleNature communicationses
dc.publication.issue7es
dc.publication.initialPage1es
dc.publication.endPage12es

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