dc.creator | Zapata Arriaza, Elena | es |
dc.creator | Mancha Molina, Fernando | es |
dc.creator | Moniche Álvarez, Francisco | es |
dc.creator | Pardo Galiana, Blanca | es |
dc.creator | Vega Salvatierra, Ángela | es |
dc.creator | Ramos Herrero, Víctor Darío | es |
dc.creator | Montaner, Joan | es |
dc.date.accessioned | 2020-03-26T16:39:35Z | |
dc.date.available | 2020-03-26T16:39:35Z | |
dc.date.issued | 2019-06-25 | |
dc.identifier.citation | Zapata Arriaza, E., Mancha Molina, F., Moniche Álvarez, F., Pardo Galiana, B., Vega Salvatierra, Á., Ramos Herrero, V.D. y Montaner, J. (2019). Biomarkers predictive value for early diagnosis of Stroke- Associated Pneumonia.. Annals of clinical and translational neurology., 6 (9), 1882-1887. | |
dc.identifier.uri | https://hdl.handle.net/11441/94601 | |
dc.description.abstract | To confirm the diagnostic accuracy of candidate biomarkers in stroke-associ-
ated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with
NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples
were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-
proADM, suPAR, SAA) were determined by immunoassays. Regarding
biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h
(P = 0.036 and P = 0.057) were associated with pneumonia. The combination
of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity
and 95.8% specificity when both biomarkers were above the cut-off. The evalu-
ated biomarkers represent promising tools to be evaluated in future large,
prospective studies on SAP. An accurate SAP diagnosis by thorax CT might
help to reduce variability in such studies. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Annals of clinical and translational neurology., 6 (9), 1882-1887. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | biomarkers. | es |
dc.subject | pneumonia. | es |
dc.subject | SAA. | es |
dc.subject | inmunoassays. | es |
dc.subject | Stroke- Associated Pneumonia. | es |
dc.title | Biomarkers predictive value for early diagnosis of Stroke- Associated Pneumonia. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Instituto de Biomedicina de Sevilla. Grupo Neurovascular. | es |
dc.relation.projectID | PI14/00971 | es |
dc.relation.projectID | REGPOT-2013-1 | es |
dc.relation.projectID | JR16/0008 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/abs/10.1002/acn3.50849 | es |
dc.identifier.doi | 10.1002/acn3.50849 | es |
dc.journaltitle | Annals of clinical and translational neurology. | es |
dc.publication.volumen | 6 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 1882 | es |
dc.publication.endPage | 1887 | es |
dc.contributor.funder | ISCIII project | es |
dc.contributor.funder | ITRIBiS project (Improving Translational Research Potential at the Institute of Biomedicine of Seville) | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |