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dc.creatorGutiérrez, Marcelinoes
dc.creatorSantamaría, Ricardoes
dc.creatorGómez Reyes, José Félixes
dc.creatorMotilva Sánchez, Virginiaes
dc.creatorTalero Barrientos, Elena Mªes
dc.creatorÁvila Román, Francisco Javieres
dc.date.accessioned2020-02-18T12:36:51Z
dc.date.available2020-02-18T12:36:51Z
dc.date.issued2020
dc.identifier.citationGutiérrez, M., Santamaría, R., Gómez Reyes, J.F., Motilva Sánchez, V., Talero Barrientos, E.M. y Ávila Román, F.J. (2020). New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum. Marine Drugs, 18 (2), 1-12.
dc.identifier.issn1660-3397es
dc.identifier.urihttps://hdl.handle.net/11441/93326
dc.description.abstractGorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofMarine Drugs, 18 (2), 1-12.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBriareumes
dc.subjectasbestininses
dc.subjectbriarellinses
dc.subjectcytokineses
dc.subjecteunicellin diterpeneses
dc.subjectyclooxygenase-2es
dc.titleNew Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinumes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttp://dx.doi.org/10.3390/md18020084es
dc.identifier.doi10.3390/md18020084es
idus.format.extent12 p.es
dc.journaltitleMarine Drugses
dc.publication.volumen18es
dc.publication.issue2es
dc.publication.initialPage1es
dc.publication.endPage12es

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