dc.creator | Claro Cala, Carmen María | es |
dc.creator | Quintela, José Carlos | es |
dc.creator | Pérez Montero , Marta | es |
dc.creator | Álvarez de Sotomayor Paz, María | es |
dc.creator | Miñano Sánchez, Francisco Javier | es |
dc.creator | Herrera González, María Dolores | es |
dc.creator | Rodríguez Rodríguez , Rosalía | es |
dc.date.accessioned | 2020-02-06T11:34:12Z | |
dc.date.available | 2020-02-06T11:34:12Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Claro Cala, C.M., Quintela, J.C., Pérez Montero , M., Álvarez de Sotomayor Paz, M., Miñano Sánchez, F.J., Herrera González, M.D. y Rodríguez Rodríguez , R. (2020). Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice. Nutrients, 12 (2), 1-13. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/92812 | |
dc.description.abstract | Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet | es |
dc.description.sponsorship | Spanish Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (Grants SAF2017-82813-C3-3-R and PCI2018-092997/AEI to R.R.-R.) | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 12 (2), 1-13. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Mediterranean diet | es |
dc.subject | maslinic acid | es |
dc.subject | obesity | es |
dc.subject | oleanolic acid | es |
dc.subject | pomace olive oil | es |
dc.subject | vascular function | es |
dc.title | Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | Grants SAF2017-82813-C3-3-R and PCI2018-092997/AEI to R.R.-R. | es |
dc.relation.publisherversion | http://dx.doi.org/10.3390/nu12020323 | es |
dc.identifier.doi | 10.3390/nu12020323 | es |
idus.format.extent | 13 p. | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 13 | es |