dc.creator | Toro López, María Dolores del | es |
dc.date.accessioned | 2019-09-06T17:15:22Z | |
dc.date.available | 2019-09-06T17:15:22Z | |
dc.date.issued | 2019-05-13 | |
dc.identifier.citation | Toro López, M.D.d. (2019). The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. Journal of Clinical Medicine, 8 (5), 1-15. | |
dc.identifier.issn | 2077-0383 | es |
dc.identifier.uri | https://hdl.handle.net/11441/89039 | |
dc.description.abstract | The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)—including multidrug-resistant organisms (MDRO)—by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama’s scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and “positive intraoperative cultures” (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2–3 months, 4–12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs. | es |
dc.description.sponsorship | Instituto de Salud Carlos III | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad PI15/1026 | es |
dc.description.sponsorship | European Regional Development Fund (FEDER) | es |
dc.description.sponsorship | European Social Fund "Investing in your future" | es |
dc.description.sponsorship | European Development Regional Fund “A way to achieve Europe” | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Journal of Clinical Medicine, 8 (5), 1-15. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | prosthetic joint infections | es |
dc.subject | microbial etiology | es |
dc.subject | classification schemes for prosthetic joint infections | es |
dc.subject | antimicrobial empirical treatment | es |
dc.subject | multidrug-resistant organisms | es |
dc.title | The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.identifier.doi | 10.3390/jcm8050673 | es |
dc.contributor.group | Universidad de Sevilla. CTS406: Estudio Enfermedades Infecciosas en la Práctica Clínica | es |
idus.format.extent | 15 | es |
dc.journaltitle | Journal of Clinical Medicine | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 15 | es |