dc.creator | Rodríguez Luna, Azahara María | es |
dc.creator | Ávila Román, Francisco Javier | es |
dc.creator | Oliveira, Helena | es |
dc.creator | Motilva Sánchez, Virginia | es |
dc.creator | Talero Barrientos, Elena Mª | es |
dc.date.accessioned | 2019-08-26T12:10:03Z | |
dc.date.available | 2019-08-26T12:10:03Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Rodríguez Luna, A.M., Ávila Román, J., Oliveira, H., Motilva Sánchez, V. y Talero Barrientos, E.M. (2019). Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes. Marine Drugs, 17 (8), 451-451-14. | |
dc.identifier.issn | 1660-3397 | es |
dc.identifier.uri | https://hdl.handle.net/11441/88707 | |
dc.description.abstract | Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin
pathologies or cancer because it encourages oxidative condition and skin inflammation. In this sense,
strategies for its prevention are currently being evaluated. Natural products such as carotenoids or
polyphenols, which are abundant in the marine environment, have been used in the prevention of
oxidative stress due to their demonstrated antioxidant activities. Nevertheless, the anti-inflammatory
activity and its implication in photo-prevention have not been extensively studied. Thus, we aimed
to evaluate the combination of fucoxanthin (FX) and rosmarinic acid (RA) on cell viability, apoptosis
induction, inflammasome regulation, and anti-oxidative response activation in UVB-irradiated HaCaT
keratinocytes. We demonstrated for the first time that the combination of FX and RA (5 µM RA plus
5 µM FX, designated as M2) improved antioxidant and anti-inflammatory profiles in comparison
to compounds assayed individually, by reducing UVB-induced apoptosis and the consequent ROS
production. Furthermore, the M2 combination modulated the inflammatory response through
down-regulation of inflammasome components such as NLRP3, ASC, and Caspase-1, and the
interleukin (IL)-1β production. In addition, Nrf2 and HO-1 antioxidant genes expression increased in
UVB-exposed HaCaT cells pre-treated with M2. These results suggest that this combination of natural
products exerts photo-protective effects by down-regulating NRLP3-inflammasome and increasing
Nrf2 signalling pathway. | es |
dc.description.sponsorship | Junta de Andalucía, Consejería de Innovación, Ciencia y Empresa-POLFANAT-P12-AGR-430 | es |
dc.description.sponsorship | Portugal, Fundação para a Ciência e a Tecnologia (FCT)-CESAM-UID/AMB/50017/2019 | es |
dc.description.sponsorship | Portugal, Fundação para a Ciência e a Tecnologia (FCT)-CEECIND/04050/2017 | es |
dc.description.sponsorship | Universidad de Sevilla "V Plan Propio US-PPI2015-1.5". | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Marine Drugs, 17 (8), 451-451-14. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fucoxanthin | es |
dc.subject | Rosmarinic acid | es |
dc.subject | NRLP3 | es |
dc.subject | Inflammasome | es |
dc.subject | Anti-oxidative | es |
dc.subject | Anti-inflammatory | es |
dc.subject | Photo-protection | es |
dc.subject | UVB | es |
dc.title | Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | POLFANAT-P12-AGR-430 | es |
dc.relation.projectID | CESAM-UID/AMB/50017/2019 | es |
dc.relation.projectID | CEECIND/04050/2017 | es |
dc.relation.projectID | V Plan Propio US-PPI2015-1.5 | es |
dc.relation.publisherversion | https://doi.org/10.3390/md17080451 | es |
dc.identifier.doi | 10.3390/md17080451 | es |
idus.format.extent | 14 p. | es |
dc.journaltitle | Marine Drugs | es |
dc.publication.volumen | 17 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 451 | es |
dc.publication.initialPage | 451-1 | es |
dc.publication.endPage | 451-14 | es |