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dc.creatorVenegas Moreno, Evaes
dc.creatorFlores Martínez, Álvaroes
dc.creatorDios, Elenaes
dc.creatorVázquez Borrego, Mari C.es
dc.creatorIbáñez Costa, Alejandroes
dc.creatorMadrazo Atutxa, Ainaraes
dc.creatorJapón Rodríguez, Miguel Ángeles
dc.creatorCastaño, Justo P.es
dc.creatorLuque, Raúl M.es
dc.creatorCano, David A.es
dc.creatorSoto Moreno, Alfonso Manueles
dc.date.accessioned2019-05-28T08:00:39Z
dc.date.available2019-05-28T08:00:39Z
dc.date.issued2019
dc.identifier.citationVenegas Moreno, E., Flores Martínez, Á., Dios, E., Vázquez Borrego, M.C., Ibáñez Costa, A., Madrazo Atutxa, A.,...,Soto Moreno, A.M. (2019). E-cadherin expression is associated with somatostatin analogue response in acromegaly. Journal of Cellular and Molecular Medicine, 23 (5), 3088-3096.
dc.identifier.issn1582-1838es
dc.identifier.issn1582-4934es
dc.identifier.urihttps://hdl.handle.net/11441/86886
dc.description.abstractAcromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs) represent the primary medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy after unsuccessful pituitary surgery. However, a considerable proportion of patients do not adequately respond to SSAs treatment, and therefore, there is an urgent need to identify biomarkers predictors of response to SSAs. The aim of this study was to examine E‐cadherin expression by immunohistochemistry in fifty‐five GH‐producing pituitary tumours and determine the potential association with response to SSAs as well as other clinical and histopathological features. Acromegaly patients with tumours expressing low E‐cadherin levels exhibit a worse response to SSAs. E‐cadherin levels are associated with GH‐producing tumour histological subtypes. Our results indicate that the immunohistochemical detection of E‐cadherin might be useful in categorizing acromegaly patients based on the response to SSAs.es
dc.description.sponsorshipISCIII‐Subdirección General de Evaluación y Fomento de la Investigación PI13/02043 PI16/00175es
dc.description.sponsorshipFEDER PI13/02043 PI16/00175es
dc.description.sponsorshipJunta de Andalucía A‐0023‐2015 A‐0003‐2016 CTS‐1406 BIO‐0139es
dc.description.sponsorshipAndalusian Ministry of Health C‐0015‐2014es
dc.description.sponsorshipCIBERobn PI13/ 02043 PI16/00175es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherWiley-Blackwelles
dc.relation.ispartofJournal of Cellular and Molecular Medicine, 23 (5), 3088-3096.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAcromegalyes
dc.subjectE-cadherines
dc.subjectPituitary tumoures
dc.subjectSomatostatin analogueses
dc.subjectSomatostatin receptores
dc.titleE-cadherin expression is associated with somatostatin analogue response in acromegalyes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationInstituto de Biomedicina de Sevilla (IBIS)es
dc.relation.projectIDPI13/02043es
dc.relation.projectIDPI16/00175es
dc.relation.projectIDA‐0023‐2015es
dc.relation.projectIDA‐0003‐2016es
dc.relation.projectIDCTS‐1406es
dc.relation.projectIDBIO‐0139es
dc.relation.projectIDC‐0015‐2014es
dc.relation.publisherversionhttps://doi.org/10.1111/jcmm.13851es
dc.identifier.doi10.1111/jcmm.13851es
idus.format.extent9 p.es
dc.journaltitleJournal of Cellular and Molecular Medicinees
dc.publication.volumen23es
dc.publication.issue5es
dc.publication.initialPage3088es
dc.publication.endPage3096es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional