dc.creator | Venegas Moreno, Eva | es |
dc.creator | Flores Martínez, Álvaro | es |
dc.creator | Dios, Elena | es |
dc.creator | Vázquez Borrego, Mari C. | es |
dc.creator | Ibáñez Costa, Alejandro | es |
dc.creator | Madrazo Atutxa, Ainara | es |
dc.creator | Japón Rodríguez, Miguel Ángel | es |
dc.creator | Castaño, Justo P. | es |
dc.creator | Luque, Raúl M. | es |
dc.creator | Cano, David A. | es |
dc.creator | Soto Moreno, Alfonso Manuel | es |
dc.date.accessioned | 2019-05-28T08:00:39Z | |
dc.date.available | 2019-05-28T08:00:39Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Venegas Moreno, E., Flores Martínez, Á., Dios, E., Vázquez Borrego, M.C., Ibáñez Costa, A., Madrazo Atutxa, A.,...,Soto Moreno, A.M. (2019). E-cadherin expression is associated with somatostatin analogue response in acromegaly. Journal of Cellular and Molecular Medicine, 23 (5), 3088-3096. | |
dc.identifier.issn | 1582-1838 | es |
dc.identifier.issn | 1582-4934 | es |
dc.identifier.uri | https://hdl.handle.net/11441/86886 | |
dc.description.abstract | Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH)
and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which
is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
represent the primary medical therapy for acromegaly and are currently used as
first‐line treatment or as second‐line therapy after unsuccessful pituitary surgery.
However, a considerable proportion of patients do not adequately respond to SSAs
treatment, and therefore, there is an urgent need to identify biomarkers predictors
of response to SSAs. The aim of this study was to examine E‐cadherin expression
by immunohistochemistry in fifty‐five GH‐producing pituitary tumours and determine
the potential association with response to SSAs as well as other clinical and
histopathological features. Acromegaly patients with tumours expressing low E‐cadherin
levels exhibit a worse response to SSAs. E‐cadherin levels are associated with
GH‐producing tumour histological subtypes. Our results indicate that the immunohistochemical
detection of E‐cadherin might be useful in categorizing acromegaly
patients based on the response to SSAs. | es |
dc.description.sponsorship | ISCIII‐Subdirección General de Evaluación y Fomento de la Investigación PI13/02043 PI16/00175 | es |
dc.description.sponsorship | FEDER PI13/02043 PI16/00175 | es |
dc.description.sponsorship | Junta de Andalucía A‐0023‐2015 A‐0003‐2016 CTS‐1406 BIO‐0139 | es |
dc.description.sponsorship | Andalusian Ministry of Health C‐0015‐2014 | es |
dc.description.sponsorship | CIBERobn PI13/ 02043 PI16/00175 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Journal of Cellular and Molecular Medicine, 23 (5), 3088-3096. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acromegaly | es |
dc.subject | E-cadherin | es |
dc.subject | Pituitary tumour | es |
dc.subject | Somatostatin analogues | es |
dc.subject | Somatostatin receptor | es |
dc.title | E-cadherin expression is associated with somatostatin analogue response in acromegaly | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.projectID | PI13/02043 | es |
dc.relation.projectID | PI16/00175 | es |
dc.relation.projectID | A‐0023‐2015 | es |
dc.relation.projectID | A‐0003‐2016 | es |
dc.relation.projectID | CTS‐1406 | es |
dc.relation.projectID | BIO‐0139 | es |
dc.relation.projectID | C‐0015‐2014 | es |
dc.relation.publisherversion | https://doi.org/10.1111/jcmm.13851 | es |
dc.identifier.doi | 10.1111/jcmm.13851 | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Journal of Cellular and Molecular Medicine | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 3088 | es |
dc.publication.endPage | 3096 | es |