dc.creator | Tarancon Diez, Laura | es |
dc.creator | Rodríguez-Gallego, Laura | es |
dc.creator | Rull, Anna | es |
dc.creator | Peraire, Joaquim | es |
dc.creator | Viladés, Consuelo | es |
dc.creator | Portilla, Irene | es |
dc.creator | Jiménez León, María Reyes | es |
dc.creator | Alba, Verónica | es |
dc.creator | Herrero, Pol | es |
dc.creator | Leal Noval, Manuel | es |
dc.creator | Ruiz-Mateos Carmona, Ezequiel | es |
dc.creator | Vidal, Francesc | es |
dc.date.accessioned | 2019-05-28T07:54:10Z | |
dc.date.available | 2019-05-28T07:54:10Z | |
dc.date.issued | 2019-03 | |
dc.identifier.citation | Tarancon Diez, L., Rodríguez-Gallego, L., Rull, A., Peraire, J., Viladés, C., Portilla, I.,...,Vidal, F. (2019). Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection. EBioMedicine, 42, 86-96. | |
dc.identifier.issn | 2352-3964 | es |
dc.identifier.uri | https://hdl.handle.net/11441/86884 | |
dc.description.abstract | Approximately 25% of elite controllers (ECs) lose their virological control by mechanisms that are
only partially known. Recently, immunovirological and proteomic factors have been associated to the loss of
spontaneous control. Our aim was to perform a metabolomic approach to identify the underlying mechanistic
pathways and potential biomarkers associated with this loss of control.
Methods: Plasma samples from EC who spontaneously lost virological control (Transient Controllers, TC, n=8),
at two and one year before the loss of control, were comparedwith a control group of ECwho persistently maintained
virological control during the same follow-up period (Persistent Controllers, PC, n=8). The determination
of metabolites and plasma lipids was performed by GC-qTOF and LC-qTOF using targeted and untargeted approaches.
Metabolite levels were associated with the polyfunctionality of HIV-specific CD8+T-cell response.
Findings: Our data suggest that, before the loss of control, TCs showed a specific circulating metabolomic profile
characterized by aerobic glycolytic metabolism, deregulated mitochondrial function, oxidative stress and
increased immunological activation. In addition, CD8+ T-cell polyfunctionality was strongly associated with metabolite
levels. Finally, valine was the main differentiating factor between TCs and PCs.
Interpretation: All these metabolomic differences should be considered not only as potential biomarkers but also
as therapeutic targets in HIV infection. | es |
dc.description.sponsorship | Instituto Carlos III PI10/02635 PI13/00796 PI16/00503 PI12/02283 PI16/00684 CPII014/00025 FI14/00431 FI17/00186 INT11/240 INT12/282 INT15/226 | es |
dc.description.sponsorship | Fondos Europeos para el Desarrollo Regional PI10/02635 PI13/00796 PI16/00503 PI12/02283 PI16/00684 CPII014/00025 FI14/00431 FI17/00186 | es |
dc.description.sponsorship | FEDER PI10/02635 PI13/00796 PI16/00503 PI12/02283 PI16/00684 CPII014/00025 FI14/00431 FI17/00186 | es |
dc.description.sponsorship | FEDER PI10/02635 PI13/00796 PI16/00503 PI12/02283 PI16/00684 CPII014/00025 FI14/00431 FI17/00186 | es |
dc.description.sponsorship | Programa de Suport als Grups de Recerca 2017SGR948 2014SGR250 | es |
dc.description.sponsorship | Gilead Fellowship Program GLD14/293 GLD17/00299 | es |
dc.description.sponsorship | Red de Investigación en Sida RD12/0017/0005 RD16/0025/0006 RD12/0017/0029 RD16/0025/0020 | es |
dc.description.sponsorship | Junta de Andalucía C-0032/17 | es |
dc.description.sponsorship | Generalitat de Catalunya PERIS SLT002/16/00101 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | EBioMedicine, 42, 86-96. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Elite controllers | es |
dc.subject | Energy metabolism | es |
dc.subject | HIV-1 | es |
dc.subject | Immunometabolism | es |
dc.subject | Loss of control | es |
dc.subject | Metabolomic profile | es |
dc.title | Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.projectID | PI10/02635 | es |
dc.relation.projectID | PI13/00796 | es |
dc.relation.projectID | PI16/00503 | es |
dc.relation.projectID | PI12/02283 | es |
dc.relation.projectID | PI16/00684 | es |
dc.relation.projectID | CPII014/00025 | es |
dc.relation.projectID | FI14/00431 | es |
dc.relation.projectID | FI17/00186 | es |
dc.relation.projectID | 2017SGR948 | es |
dc.relation.projectID | 2014SGR250 | es |
dc.relation.projectID | GLD14/293 | es |
dc.relation.projectID | GLD17/00299 | es |
dc.relation.projectID | RD12/0017/0005 | es |
dc.relation.projectID | RD16/0025/0006 | es |
dc.relation.projectID | RD12/0017/0029 | es |
dc.relation.projectID | RD16/0025/0020 | es |
dc.relation.projectID | C-0032/17 | es |
dc.relation.projectID | INT11/240 | es |
dc.relation.projectID | INT12/282 | es |
dc.relation.projectID | INT15/226 | es |
dc.relation.projectID | PERIS SLT002/16/00101 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.ebiom.2019.03.004 | es |
dc.identifier.doi | 10.1016/j.ebiom.2019.03.004 | es |
idus.format.extent | 11 p. | es |
dc.journaltitle | EBioMedicine | es |
dc.publication.volumen | 42 | es |
dc.publication.initialPage | 86 | es |
dc.publication.endPage | 96 | es |