dc.creator | Díaz Moreno, Irene | es |
dc.creator | García Heredia, José Manuel | es |
dc.creator | Díaz Quintana, Antonio Jesús | es |
dc.creator | Rosa Acosta, Miguel Ángel de la | es |
dc.date.accessioned | 2019-03-22T12:42:57Z | |
dc.date.available | 2019-03-22T12:42:57Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Díaz Moreno, I., García Heredia, J.M., Díaz Quintana, A.J. y Rosa Acosta, M.Á.d.l. (2011). Cytochrome c signalosome in mitochondria. European Biophysics Journal, 40 (12), 1301-1315. | |
dc.identifier.issn | 0175-7571 (impreso) | es |
dc.identifier.issn | 1432-1017 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/84572 | |
dc.description.abstract | Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the cytoplasmic adducts of cytochrome c that lead to cell death are amazingly stable. Interestingly, the contacts of cytochrome c with its counterparts shift from the area surrounding the heme crevice for the redox complexes to the opposite molecule side when the electron flow is not necessary. The cytochrome c signalosome shows a higher level of regulation by post-translational modifications—nitration and phosphorylation—of the hemeprotein. Understanding protein interfaces, as well as protein modifications, would puzzle the mitochondrial cytochrome c-controlled pathways out and enable the design of novel drugs to silence the action of pro-survival and pro-apoptotic partners of cytochrome c. | es |
dc.description.sponsorship | Spanish Ministry of Science and Innovation BFU2009-07190 | es |
dc.description.sponsorship | Andalusian Government BIO198 P08-CVI-3876 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | European Biophysics Journal, 40 (12), 1301-1315. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Biointeractome | es |
dc.subject | Cytochrome c | es |
dc.subject | Transient complex | es |
dc.subject | Electron transfer | es |
dc.subject | Mitochondria | es |
dc.subject | Signalosome | es |
dc.title | Cytochrome c signalosome in mitochondria | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | BFU2009-07190 | es |
dc.relation.projectID | BIO198 | es |
dc.relation.projectID | P08-CVI-3876 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1007/s00249-011-0774-4 | es |
dc.identifier.doi | 10.1007/s00249-011-0774-4 | es |
idus.format.extent | 15 p. | es |
dc.journaltitle | European Biophysics Journal | es |
dc.publication.volumen | 40 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 1301 | es |
dc.publication.endPage | 1315 | es |