Show simple item record

Article

dc.creatorKaasch, Achimes
dc.creatorBarlow, Gavines
dc.creatorEdgeworth, Jonathanes
dc.creatorFowler, Vancees
dc.creatorHellmich, Martines
dc.creatorRodríguez-Baño, Jesúses
dc.date.accessioned2019-02-26T17:55:17Z
dc.date.available2019-02-26T17:55:17Z
dc.date.issued2014
dc.identifier.citationKaasch, A., Barlow, G., Edgeworth, J., Fowler, V., Hellmich, M. y Rodríguez-Baño, J. (2014). Staphylococcus aureus bloodstream infection: A pooled analysis of five prospective, observational studies. The Journal of Infection, 68 (3), 242-251.
dc.identifier.issn1532-2742es
dc.identifier.urihttps://hdl.handle.net/11441/83529
dc.description.abstractObjectives: Staphylococcus aureus bacteraemia is a common, often fatal infection. Our aim was to describe how its clinical presentation varies between populations and to identify common determinants of outcome. Methods: We conducted a pooled analysis on 3395 consecutive adult patients with S. aureus bacteraemia. Patients were enrolled between 2006 and 2011 in five prospective studies in 20 tertiary care centres in Germany, Spain, United Kingdom, and United States. Results: The median age of participants was 64 years (interquartile range 50–75 years) and 63.8% were male. 25.4% of infections were associated with diabetes mellitus, 40.7% were nosocomial, 20.6% were caused by methicillin-resistant S. aureus (MRSA), although these proportions varied significantly across studies. Intravenous catheters were the commonest identified infective focus (27.7%); 8.3% had endocarditis. Crude 14 and 90-day mortality was 14.6% and 29.2%, respectively. Age, MRSA bacteraemia, nosocomial acquisition, endocarditis, and pneumonia were independently associated with death, but a strong association was with an unidentified infective focus (adjusted hazard ratio for 90-day mortality 2.92; 95% confidence interval 2.33 to 3.67, p < 0.0001). Conclusion: The baseline demographic and clinical features of S. aureus bacteraemia vary significantly between populations. Mortality could be reduced by assiduous MRSA control and early identification of the infective focus.es
dc.description.sponsorshipJunta de Andalucía PI 0185/2010es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherW.B. Saunders Co. Ltd.es
dc.relation.ispartofThe Journal of Infection, 68 (3), 242-251.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectStaphylococcus aureuses
dc.subjectBacteraemiaes
dc.subjectMortalityes
dc.subjectPooled analysises
dc.titleStaphylococcus aureus bloodstream infection: A pooled analysis of five prospective, observational studieses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDPI 0185/2010es
dc.identifier.doi10.1016/j.jinf.2013.10.015es
dc.contributor.groupUniversidad de Sevilla. CTS 406: Estudio Enfermedades Infecciosas en la Practica Clínicaes
idus.format.extent18es
dc.journaltitleThe Journal of Infectiones
dc.publication.volumen68es
dc.publication.issue3es
dc.publication.initialPage242es
dc.publication.endPage251es
dc.contributor.funderJunta de Andalucía

FilesSizeFormatViewDescription
Staphylococcus.pdf832.8KbIcon   [PDF] View/Open   Staphylococcus

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional