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dc.creatorOrtega de San Luís, Claraes
dc.creatorSánchez García, Manuel A.es
dc.creatorNieto González, José Luises
dc.creatorGarcía-Junco Clemente, Pabloes
dc.creatorMontero Sánchez, Adoraciónes
dc.creatorFernández-Chacón, Rafaeles
dc.creatorPascual, Albertoes
dc.date.accessioned2018-10-09T09:11:09Z
dc.date.available2018-10-09T09:11:09Z
dc.date.issued2018-06-11
dc.identifier.citationOrtega de San Luís, C., Sánchez García, M.A., Nieto González, J.L., García-Junco Clemente, P., Montero Sánchez, A., Fernández-Chacón, R. y Pascual, A. (2018). Substantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuits. Aging Cell, 17 (5), e12821-1-e12821-14.
dc.identifier.issn1474-9726es
dc.identifier.urihttps://hdl.handle.net/11441/79217
dc.description.abstractThe striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently affected in several neurological diseases. The glial cell line‐derived neurotrophic factor (GDNF), synthesized by striatal interneurons, and Sonic hedgehog (Shh), produced by the dopaminergic neurons of the substantia nigra (DA SNpc), are both involved in the nigrostriatal maintenance but the reciprocal neurotrophic relationships among these neurons are only partially understood. To define the postnatal neurotrophic connections among fast‐spiking GABAergic interneurons (FS), cholinergic interneurons (ACh), and DA SNpc, we used a genetically induced mouse model of postnatal DA SNpc neurodegeneration and separately eliminated Smoothened (Smo), the obligatory transducer of Shh signaling, in striatal interneurons. We show that FS postnatal survival relies on DA SNpc and is independent of Shh signaling. On the contrary, Shh signaling but not dopaminergic striatal innervation is required to maintain ACh in the postnatal striatum. ACh are required for DA SNpc survival in a GDNF‐independent manner. These data demonstrate the existence of three parallel but interdependent neurotrophic relationships between SN and striatal interneurons, partially defined by Shh and GDNF. The definition of these new neurotrophic interactions opens the search for new molecules involved in the striatal modulatory circuit maintenance with potential therapeutic value.es
dc.description.sponsorshipSecretaría de Estado de Investigación,Desarrollo e Innovación SAF2012-33816 SAF2015-64111-Res
dc.description.sponsorshipAgencia de Innovación y Desarrollo de Andalucía PIE13/00004 CTS2138es
dc.description.sponsorshipMinistry of Education AP2010-1598 FPU13 00530es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAnatomical Society of Great Britain and Irelandes
dc.relation.ispartofAging Cell, 17 (5), e12821-1-e12821-14.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGDNFes
dc.subjectNeurotrophic supportes
dc.subjectParkinson’s diseasees
dc.subjectShhes
dc.subjectStriatal interneuronses
dc.subjectSubstantia nigraes
dc.titleSubstantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuitses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationInstituto de Biomedicina de Sevilla (IBIS)es
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.projectIDSAF2012-33816es
dc.relation.projectIDSAF2015-64111-Res
dc.relation.projectIDPIE13/00004es
dc.relation.projectIDCTS2138es
dc.relation.projectIDAP2010-1598es
dc.relation.projectIDFPU13es
dc.relation.projectID00530es
dc.relation.publisherversionhttp://dx.doi.org/10.1111/acel.12821es
dc.identifier.doi10.1111/acel.12821es
idus.format.extent14 p.es
dc.journaltitleAging Celles
dc.publication.volumen17es
dc.publication.issue5es
dc.publication.initialPagee12821-1es
dc.publication.endPagee12821-14es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). España
dc.contributor.funderJunta de Andalucía

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