Artículo
HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation
Autor/es | Rosado Sánchez, Isaac
Herrero Fernández, Inés Genebat González, Miguel Romero, Jorge Del Riera, Melchor Podzamczer, Daniel Olalla, Julián Vidal, Francesc Muñoz-Fernández, Mª Angeles Leal Noval, Manuel Pacheco López, Yolanda María |
Departamento | Instituto de Biomedicina de Sevilla (IBIS) |
Fecha de publicación | 2018-07-18 |
Fecha de depósito | 2018-08-20 |
Publicado en |
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Resumen | Background
HIV-infected subjects with suboptimal CD4 restoration despite suppressive combined antiretroviral treatment (cART) (immunodiscordant subjects) have been classically characterized after a variable period of time ... Background HIV-infected subjects with suboptimal CD4 restoration despite suppressive combined antiretroviral treatment (cART) (immunodiscordant subjects) have been classically characterized after a variable period of time under cART. Recently, we have reported that an increased frequency of proliferating CD4 T-cells in these subjects is already present before the cART onset. The potential contribution of peripheral compensatory homeostatic proliferation (HP) is yet unknown. We aimed to analyze the expression of HP-related cellular markers on CD4 T-cells of immunodiscordant subjects before cART. Go to: Methods We analyzed the expression of OX40 and α4β7 on peripheral CD4 T-cells from immunodiscordant and control subjects (n = 21 each group) before cART initiation, and also on available follow-up samples (after 24 month of suppressive cART). Additionally, we tested the expression of these markers in an in vitro system for the study of human HP processes. Go to: Results Immunodiscordant subjects showed increased levels of OX40 and α4β7 on CD4 T-cells before cART initiation. While the cART tended to reduce these levels, immunodiscordant subjects still maintained comparatively higher levels of OX40 and α4β7 after 24 months under suppressive cART. These HP-related markers were upregulated in vitro during the human HP, especially during the fast HP. Go to: Conclusion Our results are compatible with exacerbated HP processes in immunodiscordant subjects, already before the cART onset. |
Identificador del proyecto | FIS
PI14/01693 PI13/0796 PI16/0503 CTS2593 2017SGR948 GLD14/293 RD12/0017/0029 RD16/0025/0019 RD16/0025/0006 C-0013-2017 |
Cita | Rosado Sánchez, I., Herrero-Fernández, I., Genebat González, M., Romero, J.D., Riera, M., Podzamczer, D.,...,Pacheco López, Y.M. (2018). HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation. Frontiers in Immunology, 9, 1673-1-1673-6. |
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