dc.creator | Sollier, Julie | es |
dc.creator | Townsend Stork, Caroline | es |
dc.creator | García Rubio, María Luisa | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2017-12-12T15:21:22Z | |
dc.date.available | 2017-12-12T15:21:22Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Sollier, J., Townsend Stork, C., García Rubio, M.L. y Aguilera López, A. (2014). Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability. Molecular Cell, 56 (6), 777-785. | |
dc.identifier.issn | 1097-2765 | es |
dc.identifier.uri | http://hdl.handle.net/11441/67527 | |
dc.description.abstract | R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also been associated with DNA damage accumulation and genome instability, however the mechanisms underlying R-loop induced DNA damage remain unknown. Here we demonstrate in human cells that R-loops induced by the absence of diverse RNA processing factors, including the RNA/DNA helicases Aquarius (AQR) and Senataxin (SETX), or by the inhibition of topoisomerase I, are actively processed into DNA double-strand breaks (DSBs) by the nucleotide excision repair endonucleases XPF and XPG. Surprisingly, DSB formation requires the transcription-coupled nucleotide excision repair (TC-NER) factor Cockayne syndrome group B (CSB), but not the global genome repair protein XPC. These findings reveal an unexpected and potentially deleterious role for TC-NER factors in driving R-loop-induced DNA damage and genome instability. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Molecular Cell, 56 (6), 777-785. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | R-loop | es |
dc.subject | RNA processing | es |
dc.subject | genome instability | es |
dc.subject | TC-NER | es |
dc.title | Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.molcel.2014.10.020 | es |
dc.identifier.doi | 10.1016/j.molcel.2014.10.020 | es |
idus.format.extent | 8 p. | es |
dc.journaltitle | Molecular Cell | es |
dc.publication.volumen | 56 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 777 | es |
dc.publication.endPage | 785 | es |