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dc.creatorPintado Losa, Cristinaes
dc.creatorRevilla Torres, María Elisaes
dc.creatorVizuete Chacón, María Luisaes
dc.creatorGarcía Cuervo, Luisaes
dc.creatorVitorica Ferrández, Francisco Javieres
dc.creatorRuano Caballero, Diegoes
dc.creatorCastaño Navarro, Angélicaes
dc.date.accessioned2017-12-05T19:19:08Z
dc.date.available2017-12-05T19:19:08Z
dc.date.issued2011
dc.identifier.citationPintado Losa, C., Revilla Torres, M.E., Vizuete Chacón, M.L., García Cuervo, L., Vitorica Ferrández, F.J., Ruano Caballero, D. y Castaño Navarro, A. (2011). Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density. Journal of Neuroimmunology, 238 (1-2), 44-51.
dc.identifier.issn0165-5728 (impreso)es
dc.identifier.urihttp://hdl.handle.net/11441/67291
dc.description.abstractTo elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhile the induction of the anti-inflammatory IL-10 was inversely related to cell density. Accordingly, in vivo assays showed that after LPS-injection, iNOS expression was more intense in substantia nigra, a brain area showing specific susceptibility to neurodegeneration after microglia activation, whereas IL-10 expression was more sustained in striatum, an area resistant to damage. These results support that microglia density is pivotal to control the balance between pro- and anti-inflammatory factors release.es
dc.description.sponsorshipInstituto de Salud Carlos III PI060781, PI060567es
dc.description.sponsorshipJunta de Andalucía CVI-902es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Neuroimmunology, 238 (1-2), 44-51.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeurodegenerationes
dc.subjectStriatumes
dc.subjectSubstantia nigraes
dc.subjectMicroglia densityes
dc.subjectInflammationes
dc.titleRegional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell densityes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.relation.projectIDPI060781es
dc.relation.projectIDPI060567es
dc.relation.projectIDCVI-902es
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jneuroim.2011.06.017es
dc.identifier.doi10.1016/j.jneuroim.2011.06.017es
idus.format.extent5 p.es
dc.journaltitleJournal of Neuroimmunologyes
dc.publication.volumen238es
dc.publication.issue1-2es
dc.publication.initialPage44es
dc.publication.endPage51es
dc.identifier.sisius20047655es
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderJunta de Andalucía

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Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional