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Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains

dc.creatorMartínez Martínez, Luises
dc.creatorGarcía Luque, Isabeles
dc.creatorBallesta Mudarra, Sofíaes
dc.creatorBenedí, Vicente J.es
dc.creatorHernández Allés, Santiagoes
dc.creatorPascual Hernández, Álvaroes
dc.date.accessioned2017-10-04T16:48:13Z
dc.date.available2017-10-04T16:48:13Z
dc.date.issued1998-07-01
dc.identifier.citationMartínez Martínez, L., García Luque, I., Ballesta Mudarra, S., Benedí, V.J., Hernández Allés, S. y Pascual Hernández, Á. (1998). Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains. Antimicrobial Agents and Chemotherapy, 42 (7), 1850-1852.
dc.identifier.issn0066-4804 (impreso)es
dc.identifier.issn1098-6596 (electrónico)es
dc.identifier.urihttp://hdl.handle.net/11441/65006
dc.description.abstractThe intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.es
dc.description.sponsorshipComisión Interministerial de Ciencia y Tecnología PB96-0197es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, 42 (7), 1850-1852.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEnergy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strainses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiologíaes
dc.relation.projectIDPB96-0197es
idus.format.extent3 p.es
dc.journaltitleAntimicrobial Agents and Chemotherapyes
dc.publication.volumen42es
dc.publication.issue7es
dc.publication.initialPage1850es
dc.publication.endPage1852es
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología (CICYT). España

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