Article
Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
Author/s | Martínez Martínez, Luis
García Luque, Isabel Ballesta Mudarra, Sofía Benedí, Vicente J. Hernández Allés, Santiago Pascual Hernández, Álvaro |
Department | Universidad de Sevilla. Departamento de Microbiología |
Publication Date | 1998-07-01 |
Deposit Date | 2017-10-04 |
Published in |
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Abstract | The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation ... The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents. |
Funding agencies | Comisión Interministerial de Ciencia y Tecnología (CICYT). España |
Project ID. | PB96-0197 |
Citation | Martínez Martínez, L., García Luque, I., Ballesta Mudarra, S., Benedí, V.J., Hernández Allés, S. y Pascual Hernández, Á. (1998). Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains. Antimicrobial Agents and Chemotherapy, 42 (7), 1850-1852. |
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