Artículo
Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast
Autor/es | Kajiwara, Kentaro
Ikeda, Atsuko Aguilera Romero, María Auxiliadora Castillon, Guillaume Alain Kagiwada, Satoshi Muñiz Guinea, Manuel Funato, Kouichi |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2014 |
Fecha de depósito | 2017-09-28 |
Publicado en |
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Resumen | Lipids synthesized at the endoplasmic reticulum (ER) are delivered to the Golgi by vesicular and non-vesicular pathways. ER-to-Golgi transport is crucial for maintaining the different membrane lipid composition and identities ... Lipids synthesized at the endoplasmic reticulum (ER) are delivered to the Golgi by vesicular and non-vesicular pathways. ER-to-Golgi transport is crucial for maintaining the different membrane lipid composition and identities of organelles. Despite their importance, mechanisms regulating transport remain elusive. Here we report that in yeast coat protein complex II (COPII) vesicle-mediated transport of ceramide from the ER to the Golgi requires oxysterol-binding protein homologs, Osh proteins, which have been implicated in lipid homeostasis. Because Osh proteins are not required to transport proteins to the Golgi, these results indicate a specific requirement for the Osh proteins in the transport of ceramide. In addition, we provide evidence that Osh proteins play a negative role in COPII vesicle biogenesis. Together, our data suggest that ceramide transport and sphingolipid levels between the ER and Golgi are maintained by two distinct functions of Osh proteins, which negatively regulate COPII vesicle formation and positively control a later stage, presumably fusion of ceramide-enriched vesicles with Golgi compartments. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía |
Identificador del proyecto | BFU2011-24513
P09-CVI-4503 |
Cita | Kajiwara, K., Ikeda, A., Aguilera Romero, M.A., Castillon, G.A., Kagiwada, S., Muñiz Guinea, M. y Funato, K. (2014). Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast. Journal of Cell Science, 127 (2), 376-387. |
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