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dc.creatorLópez-Escobar, Beatrizes
dc.creatorCano, David A.es
dc.creatorRojas, Anabeles
dc.creatorFelipe, Beatriz dees
dc.creatorPalma, Franciscoes
dc.creatorSánchez Alcázar, José Antonioes
dc.creatorHenderson, Deborahes
dc.creatorYbot González, Patriciaes
dc.date.accessioned2017-07-10T09:04:05Z
dc.date.available2017-07-10T09:04:05Z
dc.date.issued2015-01
dc.identifier.citationLópez-Escobar, B., Cano, D.A., Rojas, A., Felipe, B.d., Palma, F., Sánchez Alcázar, J.A.,...,Ybot González, P. (2015). The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye. DMM Disease Models and Mechanisms, 8 (2), 157-168.
dc.identifier.issn17548403es
dc.identifier.urihttp://hdl.handle.net/11441/62290
dc.description.abstractEmbryopathies that develop as a consequence of maternal diabetes have been studied intensely in both experimental and clinical scenarios. Accordingly, hyperglycaemia has been shown to downregulate the expression of elements in the non-canonical Wnt-PCP pathway, such as the Dishevelled-associated activator of morphogenesis 1 (Daam1) and Vangl2. Daam1 is a formin that is essential for actin polymerization and for cytoskeletal reorganization, and it is expressed strongly in certain organs during mouse development, including the eye, neural tube and heart. Daam1gt/gt and Daam1gt/+ embryos develop ocular defects (anophthalmia or microphthalmia) that are similar to those detected as a result of hyperglycaemia. Indeed, studying the effects of maternal diabetes on the Wnt-PCP pathway demonstrated that there was strong association with the Daam1 genotype, whereby the embryopathy observed in Daam1gt/+ mutant embryos of diabetic dams was more severe. There was evidence that embryonic exposure to glucose in vitro diminishes the expression of genes in the Wnt-PCP pathway, leading to altered cytoskeletal organization, cell shape and cell polarity in the optic vesicle. Hence, the Wnt-PCP pathway appears to influence cell morphology and cell polarity, events that drive the cellular movements required for optic vesicle formation and that, in turn, are required to maintain the fate determination. Here, we demonstrate that the Wnt-PCP pathway is involved in the early stages of mouse eye development and that it is altered by diabetes, provoking the ocular phenotype observed in the affected embryos.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherCompany of Biologists Limitedes
dc.relation.ispartofDMM Disease Models and Mechanisms, 8 (2), 157-168.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDiabeteses
dc.subjectWnt-PCP pathwayes
dc.subjectDaam1es
dc.subjectEye defectses
dc.subjectHeart defectses
dc.subjectNeural tube defectses
dc.titleThe effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eyees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationInstituto de Biomedicina de Sevilla (IBIS)es
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.contributor.affiliationCentro Andaluz de Investigaciones en Biología Molecular y Medina Regenerativa (CABIMER)es
dc.contributor.affiliationInstituto de Biomedicina de Sevilla (IBIS)es
dc.identifier.doi10.1242/dmm.017723es
idus.format.extent12es
dc.journaltitleDMM Disease Models and Mechanismses
dc.publication.volumen8es
dc.publication.issue2es
dc.publication.initialPage157es
dc.publication.endPage168es

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