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Artículo
The Role of Replication-Associated Repair Factors on R-Loops
dc.creator | Bhatia, Vaibhav | es |
dc.creator | Herrera Moyano, Emilia | es |
dc.creator | Aguilera López, Andrés | es |
dc.creator | Gómez González, Belén | es |
dc.date.accessioned | 2017-07-04T10:43:18Z | |
dc.date.available | 2017-07-04T10:43:18Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Bhatia, V., Herrera Moyano, E., Aguilera López, A. y Gómez González, B. (2017). The Role of Replication-Associated Repair Factors on R-Loops. Genes, 8 (7), 171-. | |
dc.identifier.issn | 2073-4425 | es |
dc.identifier.uri | http://hdl.handle.net/11441/61936 | |
dc.description.abstract | The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication processes and lead to genomic instability by a mechanism still not fully understood. In this sense, a connection between R-loops and certain chromatin markers has been reported that might play a key role in R-loop homeostasis and genome instability. To counteract the potential harmful effect of R-loops, different conserved messenger ribonucleoprotein (mRNP) biogenesis and nuclear export factors prevent R-loop formation, while ubiquitously-expressed specific ribonucleases and DNA-RNA helicases resolve DNA-RNA hybrids. However, the molecular events associated with R-loop sensing and processing are not yet known. Given that R-loops hinder replication progression, it is plausible that some DNA replication-associated factors contribute to dissolve R-loops or prevent R-loop mediated genome instability. In support of this, R-loops accumulate in cells depleted of the BRCA1, BRCA2 or the Fanconi anemia (FA) DNA repair factors, indicating that they play an active role in R-loop dissolution. In light of these results, we review our current view of the role of replication-associated DNA repair pathways in preventing the harmful consequences of R-loops. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Genes, 8 (7), 171-. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Genetic instability | es |
dc.subject | DNA-RNA hybrids | es |
dc.subject | Fanconi anemia | es |
dc.subject | BRCA | es |
dc.subject | Replication stress | es |
dc.subject | Cancer | es |
dc.title | The Role of Replication-Associated Repair Factors on R-Loops | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://dx.doi.org/10.3390/genes8070171 | es |
dc.identifier.doi | 10.3390/genes8070171 | es |
dc.journaltitle | Genes | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 171 | es |
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The role of replication.pdf | 983.3Kb | [PDF] | Ver/ | |