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dc.creatorPolaino, Silviaes
dc.creatorVillalobos Escobedo, José M.es
dc.creatorMiralles Durán, Alejandroes
dc.creatorLuque Fobelo, Eva Milagroses
dc.creatorCorrochano Peláez, Luis Maríaes
dc.date.accessioned2017-06-12T13:30:03Z
dc.date.available2017-06-12T13:30:03Z
dc.date.issued2017
dc.identifier.citationPolaino, S., Villalobos Escobedo, J.M., Miralles Durán, A., Luque Fobelo, E.M. y Corrochano Peláez, L.M. (2017). A Ras GTPase associated protein is involved in the phototropic and circadian photobiology responses in fungi. Scientific Reports, 7 (4479), 1-12.
dc.identifier.issn2045-2322es
dc.identifier.urihttp://hdl.handle.net/11441/61234
dc.description.abstractLight is an environmental signal perceived by most eukaryotic organisms and that can have major impacts on their growth and development. The MadC protein in the fungus Phycomyces blakesleeanus (Mucoromycotina) has been postulated to form part of the photosensory input for phototropism of the fruiting body sporangiophores, but the madC gene has remained unidentified since the 1960s when madC mutants were first isolated. In this study the madC gene was identified by positional cloning. All madC mutant strains contain loss-of-function point mutations within a gene predicted to encode a GTPase activating protein (GAP) for Ras. The madC gene complements the Saccharomyces cerevisiae Ras-GAP ira1 mutant and the encoded MadC protein interacts with P. blakesleeanus Ras homologs in yeast two-hybrid assays, indicating that MadC is a regulator of Ras signaling. Deletion of the homolog in the filamentous ascomycete Neurospora crassa affects the circadian clock output, yielding a pattern of asexual conidiation similar to a ras-1 mutant that is used in circadian studies in N. crassa. Thus, MadC is unlikely to be a photosensor, yet is a fundamental link in the photoresponses from blue light perceived by the conserved White Collar complex with Ras signaling in two distantly-related filamentous fungal species.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.relation.ispartofScientific Reports, 7 (4479), 1-12.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleA Ras GTPase associated protein is involved in the phototropic and circadian photobiology responses in fungies
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.publisherversionhttp://dx.doi.org/10.1038/srep44790es
dc.identifier.doi10.1038/srep44790es
idus.format.extent13 p.es
dc.journaltitleScientific Reportses
dc.publication.volumen7es
dc.publication.issue4479es
dc.publication.initialPage1es
dc.publication.endPage12es

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Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional